Thieno[3,2-b]pyridin-7-ol

Base Information

• Chemical Name: Thieno[3,2-b]pyridin-7-ol
• CAS No.: 107818-20-2
• Molecular Formula: C₇H₅NOS
• Molecular Weight: 151.189
• Hs Code.: 29349990
• European Community (EC) Number: 626-962-7
• DSSTox Substance ID: DTXSID20408069
• Nikkaji Number: J2.050.457I
• Wikidata: Q27466710
• Mol file: 107818-20-2.mol

Synonyms:Thieno[3,2-b]pyridin-7-ol;107818-20-2;thieno[3,2-b]pyridin-7(4H)-one;69627-02-7;4H-thieno[3,2-b]pyridin-7-one;THIENO(3 2-B)PYRIDIN-7-OL;Thieno(3,2-B)pyridin-7-OL;7-HYDROXYTHIENO[3,2-B]PYRIDINE;MFCD01863636;BIDD:GT0268;SCHEMBL105581;thieno[3,2,b]pyridin-7-ol;DTXSID20408069;AACVULYSNJAKEQ-UHFFFAOYSA-N;Thieno-(3,2-B)-pyridin-7-ol;4H-thieno[3,2-b]pyridine-7-one;BCP27004;CX1280;MFCD12964174;Thieno[3,2-b]pyridin-7-ol, 94%;AKOS009156544;AKOS015918999;AC-4399;CS-W002859;FS-2637;PB32284;SB10353;SY004858;AM20050654;CS-0166785;FT-0649107;FT-0732146;H1603;EN300-84887;A15100;J-002017;J-524933;Q27466710;Z1948933786;TR2

Chemical Property of Thieno[3,2-b]pyridin-7-ol

Chemical Property:

• Vapor Pressure: 0.000622mmHg at 25°C
• Melting Point: 230-235 °C(lit.)
• Refractive Index: 1.54
• Boiling Point: 321.421 °C at 760 mmHg
• PKA: 4.05±0.40(Predicted)
• Flash Point: 148.19 °C
• PSA: 61.36000
• Density: 1.444 g/cm³
• LogP: 2.00190
• Storage Temp.: Sealed in dry,Room Temperature
• Water Solubility.: Soluble in water.
• XLogP3: 1.6
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 0
• Exact Mass: 151.00918496
• Heavy Atom Count: 10
• Complexity: 190

Purity/Quality:

98%,99%, ^*data from raw suppliers

Thieno[3,2-B]pyridin-7-ol ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CNC2=C(C1=O)SC=C2
• Uses: Thieno[3,2-b]pyridin-7-ol may be used in the synthesis of 7-bromothieno[3,2-b]pyridine.

Technology Process of Thieno[3,2-b]pyridin-7-ol

There total 1 articles about Thieno[3,2-b]pyridin-7-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,2-dimethyl-5-{[(thiophen-3-yl)amino]methylidene}-1,3-dioxane-4,6-dione (913377-45-4) → thieno[3,2-b]pyridin-7-ol (69627-02-7,107818-20-2)

Guidance literature:

In diphenylether; at 20 - 200 ℃;

Reference yield: 96.0%

thieno[3,2-b]pyridin-7-ol (69627-02-7,107818-20-2) → 7-chlorothieno[3,2-b]pyridine (69627-03-8)

Guidance literature:

thieno[3,2-b]pyridin-7-ol; With trichlorophosphate; at 60 - 100 ℃; for 3.5h;

With ammonia; water; at 0 ℃;

Reference yield: 89.5%

thieno[3,2-b]pyridin-7-ol (69627-02-7,107818-20-2) → 7-bromothieno[3,2-b]pyridine (603305-89-1)

Guidance literature:

thieno[3,2-b]pyridin-7-ol; With phosphorus(V) oxybromide; at 69 - 100 ℃; for 2h;

With sodium hydroxide; In water; pH=10 - 11;

upstream raw materials:

2,2-dimethyl-5-{[(thiophen-3-yl)amino]methylidene}-1,3-dioxane-4,6-dione

Downstream raw materials:

7-[(1R)-(3-chloro-1-phenyl-propoxy)]-thieno[3,2-b]pyridine

7-bromothieno[3,2-b]pyridine

C₇H₄ClNOS

4-[2-hydroxy-4-(5-methanesulfonyl-2,3-dihydrobenzofuran-7-yl)-4-methyl-2-trifluoromethylpentyl]-4H-thieno[3,2-b]pyridin-7-one

Refernces