H-PHG-OME HCL

Base Information

• Chemical Name: H-PHG-OME HCL
• CAS No.: 13226-98-7
• Molecular Formula: C₉H₁₁NO₂*ClH
• Molecular Weight: 201.653
• Hs Code.: 2922499990
• Mol file: 13226-98-7.mol

Synonyms:Benzeneaceticacid, a-amino-, methyl ester,hydrochloride (9CI);Benzeneacetic acid, a-amino-, methyl ester, hydrochloride, (?à)-;Glycine, 2-phenyl-, methylester, hydrochloride, DL- (8CI);(DL)-Methyl phenylglycinate hydrochloride;2-Methoxy-2-oxo-1-phenylethylamine hydrochloride;DL-2-Phenylglycine methylester hydrochloride;DL-Phenylglycine methyl ester hydrochloride;DL-a-Phenylglycine methyl esterhydrochloride;Methyl (?à)-phenylglycinate hydrochloride;Methyl DL-phenylglycine hydrochloride;Methyl phenylglycinate hydrochloride;Methyl a-aminophenylacetate hydrochloride;Methyl a-phenylglycinate hydrochloride;

Chemical Property of H-PHG-OME HCL

Chemical Property:

• Vapor Pressure: 0.0013mmHg at 25°C
• Melting Point: 200 °C (dec.)(lit.)
• Boiling Point: 293.4 °C at 760 mmHg
• Flash Point: 131.3 °C
• PSA: 52.32000
• LogP: 2.36170

Purity/Quality:

99% ^*data from raw suppliers

Methyl(S)-2-amino-2-phenylacetatehydrochloride 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36
• Safety Statements: 26-36/37

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of H-PHG-OME HCL

There total 63 articles about H-PHG-OME HCL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(S)-methyl 2-((S)-1-phenylethylamino)-2-phenylacetate (235786-93-3) → L-2-phenylglycine methyl ester hydrochloride (15028-39-4,13226-98-7)

Guidance literature:

With hydrogenchloride; hydrogen; palladium dihydroxide; In methanol; for 15h; under 760.051 Torr;

DOI:10.1002/anie.200704689

Reference yield: 99.0%

methanol (67-56-1) + (S)-2-phenylglycine (2935-35-5) → L-2-phenylglycine methyl ester hydrochloride (15028-39-4,13226-98-7)

Guidance literature:

With thionyl chloride; for 10h; Ambient temperature;

DOI:10.1021/jo00298a019

Reference yield: 99.0%

(S)-2-phenylglycine (2935-35-5) + 2,2-dimethoxy-propane (77-76-9) → L-2-phenylglycine methyl ester hydrochloride (15028-39-4,13226-98-7)

Guidance literature:

With hydrogenchloride; In water; at 20 ℃;

DOI:10.1002/asia.201901470

upstream raw materials:

(S)-Methyl mandelate

N-benzylidene benzylamine

carbonic acid dimethyl ester

methanol

Downstream raw materials:

N-<(R)-1-Methoxycarbonylbenzyl>-(2R,5S)-2,5-dimethyl-3,4-didehydropiperidin

N-<(R)-1-Methoxycarbonylbenzyl>-(2S,5R)-2,5-dimethyl-3,4-didehydropiperidin

N-<(S)-1-Methoxycarbonylbenzyl>-(2R)-2,4-dimethyl-3,4-didehydropiperidin

N-<(S)-1-Methoxycarbonylbenzyl>-(2S)-2,4-dimethyl-3,4-didehydropiperidin

Refernces

• 1、 Nagai, Yuriko,Kusumi, Takenori. "New Chiral Anisotropic Reagents for Determining the Absilute Configuration of Carboxylic Acids". . p. 1853 - 1856. Retrieved 1995.
• 2、 Kihlberg, Tor,Karimi, Farhad,Langstroem, Bengt. "[(11)C] Carbon monoxide in selenium-mediated synthesis of (11)C-carbamoyl compounds.". . p. 3687 - 3692. Retrieved 2002.
• 3、 Zeng, Wanting,Nukeyeva, Moldir,Wang, Qiumei,Jiang, Chao. "Synthesis of unnatural α-amino acid derivatives: Via selective o -C-H functionalization". . p. 598 - 608. Retrieved 2018.
• 4、 Lamaty, Frederic,Lazaro, Rene,Martinez, Jean. "Efficient synthesis of functionalized α-aryl α-aminoesters via reaction of polyfunctional diarylzincs with a glycine cation equivalent". . p. 3385 - 3386. Retrieved 1997.
• 5、 Uemura, Takahito,Saito, Yusuke,Sonoda, Motohiro,Tanimori, Shinji. "A Concise Enantiodivergent Synthesis of Equol". . p. 693 - 696. Retrieved 2020/12/23.
• 6、 Decuyper, Lena,Juki?, Marko,Sosi?, Izidor,Amoroso, Ana Maria,Verlaine, Olivier,Joris, Bernard,Gobec, Stanislav,D'hooghe, Matthias. "Synthesis and Penicillin-binding Protein Inhibitory Assessment of Dipeptidic 4-Phenyl-β-lactams from α-Amino Acid-derived Imines". supporting information. p. 51 - 55. Retrieved 2019/11/28.