5-ACETALDEHYDEYL-4,6-DICHLOROPYRIMIDINE

Base Information

• Chemical Name: 5-ACETALDEHYDEYL-4,6-DICHLOROPYRIMIDINE
• CAS No.: 16019-33-3
• Molecular Formula: C6H4Cl2N2O
• Molecular Weight: 191.017
• Hs Code.: 2933399990
• Mol file: 16019-33-3.mol

Synonyms:2-(4,6-Dichloro-5-pyrimidinyl)acetaldehyde;(4,6-Dichloro-pyrimidin-5-yl)-acetaldehyde;4,6-Dichloro-5-pyrimidineacetaldehyde;5-Acetaldehydeyl-4,6-dichloropyrimidine;

Chemical Property of 5-ACETALDEHYDEYL-4,6-DICHLOROPYRIMIDINE

Chemical Property:

• Melting Point: 89-91 °C(Solv: dichloromethane (75-09-2); heptane (142-82-5))
• Refractive Index: 1.559
• Boiling Point: 312.714 °C at 760 mmHg
• PKA: -4.49±0.26(Predicted)
• Flash Point: 142.924 °C
• PSA: 42.85000
• Density: 1.47 g/cm³
• LogP: 1.52480
• Storage Temp.: Inert atmosphere,Store in freezer, under -20°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-(4,6-Dichloropyrimidin-5-yl)acetaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-ACETALDEHYDEYL-4,6-DICHLOROPYRIMIDINE

There total 10 articles about 5-ACETALDEHYDEYL-4,6-DICHLOROPYRIMIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

4,6-dichloropyrimidine-5-acetaldehyde-O-methyloxime → 2-(4,6-dichloropyrimidin-5-yl)acetaldehyde (16019-33-3)

Guidance literature:

With formaldehyd; In water; acetone; at 40 ℃; for 12h;

Reference yield: 88.0%

5-allyl-4,6-dichloropyrimidine (16019-31-1) → 2-(4,6-dichloropyrimidin-5-yl)acetaldehyde (16019-33-3)

Guidance literature:

With ozone; triethylamine; In dichloromethane; dimethyl sulfoxide; at -40 ℃; for 0.5h; Inert atmosphere;

Reference yield: 87.0%

5-[(1,3-dithiolan-2-yl)methyl]-4,6-dichloropyrimidine → 2-(4,6-dichloropyrimidin-5-yl)acetaldehyde (16019-33-3)

Guidance literature:

With water; calcium carbonate; mercury dichloride; In acetonitrile; at 20 ℃; for 6h;

upstream raw materials:

5-allyl-4,6-dichloropyrimidine

5-(prop-2-en-1-yl)pyrimidine-4,6-diol

(2-propenyl)propanedioic acid diethyl ester

5-allyl-6-hydroxy-3H-pyrimidin-4-one

Downstream raw materials:

2-(4,6-dichloropyrimidin-5-yl)ethanol

4-chloro-7-(3-methoxy-phenyl)-7H-pyrrolo[2,3-d]pyrimidine

[7-(3-methoxy-phenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]-hydrazine

(6-chloro-5-[1,3]dioxolan-2-ylmethyl-pyrimidin-4-yl)-(3-methoxy-phenyl)-amine

Refernces

• 1、 -. "Method for preparing 4, 6-dichloropyrimidine-5-acetaldehyde". Paragraph 0038; 0041-0043. . Retrieved 2019/04/26.
• 2、 -. "4-chloro-7H-pyrrolo[2,3-d]pyrimidine synthetic method". Paragraph 0038; 0040; 0043; 0046; 0048; 0049; 0052. . Retrieved 2018/09/11.