Technology Process of (S)-3-[(R)-3-hydroxy-3-phenylpropanoyl]-4-isopropyl-1-[(R)-1-phenylethyl]imidazolidin-2-one
There total 7 articles about (S)-3-[(R)-3-hydroxy-3-phenylpropanoyl]-4-isopropyl-1-[(R)-1-phenylethyl]imidazolidin-2-one which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
N-acetyl-(S)-4-isopropyl-1-[(R)-1-phenylethyl] imidazolidin-2-one;
With
titanium tetrachloride;
In
dichloromethane;
at -78 - 0 ℃;
Inert atmosphere;
With
N-ethyl-N,N-diisopropylamine;
In
dichloromethane;
at -78 ℃;
for 1h;
Inert atmosphere;
benzaldehyde;
In
dichloromethane;
at -78 ℃;
for 0.5h;
diastereoselective reaction;
DOI:10.1021/ol300949s
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: lithium aluminium tetrahydride / tetrahydrofuran / 12 h / Inert atmosphere; Reflux
2.1: potassium carbonate / water; toluene / 0 - 20 °C
3.1: sodium hydride / tetrahydrofuran; paraffin oil / 1 h / 0 °C / Inert atmosphere
3.2: Inert atmosphere
4.1: titanium tetrachloride / dichloromethane / -78 - 0 °C / Inert atmosphere
4.2: 1 h / -78 °C / Inert atmosphere
4.3: 0.5 h / -78 °C
With
lithium aluminium tetrahydride; titanium tetrachloride; sodium hydride; potassium carbonate;
In
tetrahydrofuran; dichloromethane; water; toluene; paraffin oil;
4.1: Aldol reaction / 4.2: Aldol reaction / 4.3: Aldol reaction;
DOI:10.1021/ol300949s
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: potassium carbonate / water; toluene / 0 - 20 °C
2.1: sodium hydride / tetrahydrofuran; paraffin oil / 1 h / 0 °C / Inert atmosphere
2.2: Inert atmosphere
3.1: titanium tetrachloride / dichloromethane / -78 - 0 °C / Inert atmosphere
3.2: 1 h / -78 °C / Inert atmosphere
3.3: 0.5 h / -78 °C
With
titanium tetrachloride; sodium hydride; potassium carbonate;
In
tetrahydrofuran; dichloromethane; water; toluene; paraffin oil;
3.1: Aldol reaction / 3.2: Aldol reaction / 3.3: Aldol reaction;
DOI:10.1021/ol300949s