N-L-leucyl-L-phenylalanine ethyl ester; hydrochloride

Base Information

• Chemical Name: N-L-leucyl-L-phenylalanine ethyl ester; hydrochloride
• CAS No.: 74973-89-0
• Molecular Formula: C₁₇H₂₆N₂O₃*ClH
• Molecular Weight: 342.866
• Mol file: 74973-89-0.mol

Synonyms:N-L-leucyl-L-phenylalanine ethyl ester; hydrochloride

Chemical Property of N-L-leucyl-L-phenylalanine ethyl ester; hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-L-leucyl-L-phenylalanine ethyl ester; hydrochloride

There total 6 articles about N-L-leucyl-L-phenylalanine ethyl ester; hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.5%

ethyl N-benzyloxycarbonyl-L-leucyl-L-phenylalaninate (3005-89-8) → N-L-leucyl-L-phenylalanine ethyl ester; hydrochloride (74973-89-0)

Guidance literature:

With hydrogenchloride; palladium on charcoal; In ethanol;

Reference yield:

Z-Leu-OH (2018-66-8) → N-L-leucyl-L-phenylalanine ethyl ester; hydrochloride (74973-89-0)

Guidance literature:

Multi-step reaction with 2 steps

1: chlorocarbonic acid ethyl ester

2: palladium; aqueous methanol. HCl / Hydrogenation

With hydrogenchloride; chloroformic acid ethyl ester; palladium;

DOI:10.1021/ja01521a036

Reference yield:

H-Phe-OEt (3081-24-1) → N-L-leucyl-L-phenylalanine ethyl ester; hydrochloride (74973-89-0)

Guidance literature:

Multi-step reaction with 2 steps

1: chlorocarbonic acid ethyl ester

2: palladium; aqueous methanol. HCl / Hydrogenation

With hydrogenchloride; chloroformic acid ethyl ester; palladium;

DOI:10.1021/ja01521a036

upstream raw materials:

hydrogenchloride

ethyl N-benzyloxycarbonyl-L-leucyl-L-phenylalaninate

Z-Leu-OH

H-Phe-OEt

Refernces