3-benzyl-2,4-dimethyl-1H-pyrrole

Base Information

• Chemical Name: 3-benzyl-2,4-dimethyl-1H-pyrrole
• CAS No.: 857418-66-7
• Molecular Formula: C₁₃H₁₅N
• Molecular Weight: 185.269
• Mol file: 857418-66-7.mol

Synonyms:3-benzyl-2,4-dimethyl-1H-pyrrole

Chemical Property of 3-benzyl-2,4-dimethyl-1H-pyrrole

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 3-benzyl-2,4-dimethyl-1H-pyrrole

There total 4 articles about 3-benzyl-2,4-dimethyl-1H-pyrrole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

benzyl bromide (100-39-0) → 3-benzyl-2,4-dimethyl-1H-pyrrole (857418-66-7)

Guidance literature:

Multi-step reaction with 4 steps

1.1: sodium carbonate / acetone / 24.5 h / 0 °C / Reflux

2.1: acetic acid; sodium nitrite / water / 12 h / 0 - 20 °C

2.2: 1.5 h / 15 - 80 °C

3.1: sodium hydroxide / ethanol; water / 5 h / Reflux

4.1: trifluoroacetic acid / 0.08 h / 20 °C / Inert atmosphere

With sodium carbonate; acetic acid; trifluoroacetic acid; sodium hydroxide; sodium nitrite; In ethanol; water; acetone;

DOI:10.1039/c5cp01741f

Reference yield:

3-benzyl-pentane-2,4-dione (1134-87-8) → 3-benzyl-2,4-dimethyl-1H-pyrrole (857418-66-7)

Guidance literature:

Multi-step reaction with 3 steps

1.1: acetic acid; sodium nitrite / water / 12 h / 0 - 20 °C

1.2: 1.5 h / 15 - 80 °C

2.1: sodium hydroxide / ethanol; water / 5 h / Reflux

3.1: trifluoroacetic acid / 0.08 h / 20 °C / Inert atmosphere

With acetic acid; trifluoroacetic acid; sodium hydroxide; sodium nitrite; In ethanol; water;

DOI:10.1039/c5cp01741f

Reference yield:

ethyl 4-benzyl-3,5-dimethyl-1H-pyrrole-2-carboxylate (131475-13-3) → 3-benzyl-2,4-dimethyl-1H-pyrrole (857418-66-7)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydroxide / ethanol; water / 5 h / Reflux

2: trifluoroacetic acid / 0.08 h / 20 °C / Inert atmosphere

With trifluoroacetic acid; sodium hydroxide; In ethanol; water;

DOI:10.1021/acs.joc.5b00654 DOI:10.1039/c5cp01741f

upstream raw materials:

(2,4-dimethyl-1H-pyrrol-3-yl)(phenyl)methanone

benzyl bromide

ethyl 4-benzyl-3,5-dimethyl-1H-pyrrole-2-carboxylate

3-benzyl-pentane-2,4-dione

Refernces

• 1、 Thorat, Kishor G.,Kamble, Priyadarshani,Ray, Alok K.,Sekar, Nagaiyan. "Novel pyrromethene dyes with N-ethyl carbazole at the meso position: a comprehensive photophysical, lasing, photostability and TD-DFT study". . p. 17221 - 17236. Retrieved 2015/07/02.