2-(3,4-Dimethoxyphenyl)-3-methyl-buttersaeuremethylester

Base Information

• Chemical Name: 2-(3,4-Dimethoxyphenyl)-3-methyl-buttersaeuremethylester
• CAS No.: 58139-64-3
• Molecular Formula: C₁₄H₂₀O₄
• Molecular Weight: 252.31
• Mol file: 58139-64-3.mol

Synonyms:2-(3,4-Dimethoxyphenyl)-3-methyl-buttersaeuremethylester

Chemical Property of 2-(3,4-Dimethoxyphenyl)-3-methyl-buttersaeuremethylester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(3,4-Dimethoxyphenyl)-3-methyl-buttersaeuremethylester

There total 1 articles about 2-(3,4-Dimethoxyphenyl)-3-methyl-buttersaeuremethylester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-iodo-propane (75-30-9) + methyl (3,4-dimethoxyphenyl)acetate (15964-79-1) → 2-(3,4-Dimethoxyphenyl)-3-methyl-buttersaeuremethylester (58139-64-3)

Guidance literature:

Multistep reaction; (i) NaNH₂, Fe(NO₃)3, liq. NH₃, (ii) /BRN= 1098244/;

DOI:10.1002/hlca.19750580720

Reference yield:

2-(3,4-Dimethoxyphenyl)-3-methyl-buttersaeuremethylester (58139-64-3) → (S)-verapamil (36622-29-4,56949-77-0)

Guidance literature:

Multi-step reaction with 5 steps

1: (i) NaNH₂, Fe(NO₃)3, liq. NH₃, (ii) /BRN= 605308/

2: aq. KOH / dimethylsulfoxide / 48 h / 90 °C

3: (i) PCl₅, Et₂O, (ii) liq. NH₃, bis-(2,3-dimethyl-propyl)-borane, THF, (iii) aq. H₂O₂

4: 2,2,2-trichloro-<1,3,2>benzodioxaphospholane / 100 °C

5: 4 h / 130 °C

With potassium hydroxide; trichloro(o-phenylenedioxy)phosphorane; In dimethyl sulfoxide;

DOI:10.1002/hlca.19750580720

Reference yield:

2-(3,4-Dimethoxyphenyl)-3-methyl-buttersaeuremethylester (58139-64-3) → dexverapamil (38321-02-7,56949-77-0)

Guidance literature:

Multi-step reaction with 5 steps

1: (i) NaNH₂, Fe(NO₃)3, liq. NH₃, (ii) /BRN= 605308/

2: aq. KOH / dimethylsulfoxide / 48 h / 90 °C

3: (i) PCl₅, Et₂O, (ii) liq. NH₃, bis-(2,3-dimethyl-propyl)-borane, THF, (iii) aq. H₂O₂

4: 2,2,2-trichloro-<1,3,2>benzodioxaphospholane / 100 °C

5: 4 h / 130 °C

With potassium hydroxide; trichloro(o-phenylenedioxy)phosphorane; In dimethyl sulfoxide;

DOI:10.1002/hlca.19750580720

upstream raw materials:

2-iodo-propane

methyl (3,4-dimethoxyphenyl)acetate

Downstream raw materials:

dexverapamil

(+/-)-2-(3,4-Dimethoxyphenyl)-2-isopropyl-pent-4-en-carbonsaeure

(S)-verapamil

(S)-2-Isopropyl-2-methyl-succinic acid dibenzyl ester

Refernces