hydrocinchonine

Base Information

• Chemical Name: hydrocinchonine
• CAS No.: 73522-74-4
• Molecular Formula: C₁₉H₂₄N₂O
• Molecular Weight: 296.412
• Mol file: 73522-74-4.mol

Synonyms:hydrocinchonine

Chemical Property of hydrocinchonine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of hydrocinchonine

There total 2 articles about hydrocinchonine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

pentan-1-ol (71-41-0) + dihydrocinchonine (485-65-4) → hydrocinchonine (73522-74-4) + (-)-hydrocinchonidine (485-64-3) + hydrocinchonidine (73522-73-3)

Guidance literature:

Reference yield:

→ 10,11-dihydro-cinchonan-9-ol (485-64-3,485-65-4,26599-43-9,26695-56-7,73522-73-3,73522-74-4)

Guidance literature:

Hexahydrocinchonin, Quecksilberacetat;

Reference yield:

hydrocinchonidine (485-64-3,485-65-4,26599-43-9,26695-56-7,73522-73-3,73522-74-4) → 4-Azido-N-{4-[(R)-((2S,5R)-5-ethyl-1-aza-bicyclo[2.2.2]oct-2-yl)-hydroxy-methyl]-quinolin-8-yl}-2-hydroxy-3,5-diiodo-benzamide

Guidance literature:

Multi-step reaction with 5 steps

1: HNO₃; H₂SO₄ / 7 h / 20 °C

2: 52 percent / N₂H₄*H₂O / Pd/C / ethanol / 1 h / Heating

3: 0.51 g / dioxane / Heating

4: aq. Na₂B₄O₇ / ethanol / 1.5 h / pH 9.2 / Heating

5: NaI; chloramine T / aq. phosphate buffer; dimethylformamide / 0.33 h / 20 °C / pH 7.4

With borax; sulfuric acid; nitric acid; chloroamine-T; hydrazine hydrate; sodium iodide; palladium on activated charcoal; In 1,4-dioxane; phosphate buffer; ethanol; N,N-dimethyl-formamide; 1: Nitration / 2: Reduction / 3: Condensation / 4: Hydrolysis / 5: Iodination;

DOI:10.1002/1099-1344(200009)43:10<977::AID-JLCR382>3.0.CO;2-E

upstream raw materials:

pentan-1-ol

dihydrocinchonine