Cyclohexane, 1-chloro-1-nitroso-

Base Information

• Chemical Name: Cyclohexane, 1-chloro-1-nitroso-
• CAS No.: 695-64-7
• Molecular Formula: C6H10 Cl N O
• Molecular Weight: 147.605
• Mol file: 695-64-7.mol

Synonyms:1-Chloro-1-nitrosocyclohexane

Chemical Property of Cyclohexane, 1-chloro-1-nitroso-

Chemical Property:

• Melting Point: 116.5°C
• Refractive Index: 1.4870 (estimate)
• Boiling Point: 62-63 °C(Press: 22 Torr)
• PSA: 29.43000
• Density: 1.1140
• LogP: 2.65200

Purity/Quality:

99% ^*data from raw suppliers

1-Chloro-1-nitrosocyclohexane ^*data from reagent suppliers

Safty Information:

• Pictogram(s): 3
• Hazard Codes: 3:
• Safety Statements: May explode during vacuum distillation. When heated to decomposition it emits toxic fumes of C"> − and NOx." target="_blank">May explode during vacuum distillation. When heated to decomposition it emits toxic fumes of C

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Cyclohexane, 1-chloro-1-nitroso-

There total 9 articles about Cyclohexane, 1-chloro-1-nitroso- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

cyclohexanone-oxime (100-64-1) + N,N'-dichlorobis(2,4,6-trichlorodiphenyl)urea (2899-02-7,99515-28-3) → 1-chloro-1-nitrosocyclohexane (695-64-7) + bis(2,4,6-trichlorodiphenyl)urea (20632-35-3)

Guidance literature:

In acetonitrile; at 20 ℃; for 0.333333h;

DOI:10.1016/j.tetlet.2006.12.001

Reference yield: 40.0%

cyclohexanone-oxime (100-64-1) → 1-chloro-1-nitrosocyclohexane (695-64-7) + 1-chloro-1-nitrocyclohexane (873-92-7)

Guidance literature:

With chloro-trimethyl-silane; nitro acetate; In dichloromethane; at -10 ℃;

DOI:10.1007/s12039-010-0091-y

Reference yield: 28.0%

1-nitrocyclohexane (1122-60-7) → 1-chloro-1-nitrosocyclohexane (695-64-7)

Guidance literature:

1-nitrocyclohexane; With n-butyllithium; potassium tert-butylate; In diethyl ether; at 0 ℃; for 0.5h; Inert atmosphere;

With oxalyl dichloride; for 0.25h;

DOI:10.1016/j.tetlet.2010.11.031

upstream raw materials:

cyclohexane

hydrogenchloride

cyclohexanone-oxime

chlorine

Downstream raw materials:

2-oxa-3-azabicyclo[2.2.2]oct-5-ene

(2S,5S)-3-Benzyl-5-cyclohexylideneaminooxy-2-ethoxy-2,5-diphenyl-thiazolidin-4-one

(2S,5S)-3-(4-Chloro-phenyl)-5-cyclohexylideneaminooxy-2-ethoxy-2,5-diphenyl-thiazolidin-4-one

1,1-diethoxycyclohexane

Refernces

• 1、 Bou-Moreno, Rafael,Luengo-Arratta, Sandra,Motherwell, William B.. "Observations on the reaction of nitronate anions with oxalyl chloride: A new method for the preparation of geminal chloronitroso compounds". supporting information; experimental part. p. 2097 - 2099. Retrieved 2011/05/09.
• 2、 Gupta,Acharya,Pardasani,Dubey. "N,N′-Dichloro bis(2,4,6-trichlorophenyl)urea (CC-2): an efficient reagent for the synthesis of α-chloro-nitroso compounds". . p. 767 - 770. Retrieved 2007/10/03.