N-PHTHALOYL-DL-GLUTAMIC ANHYDRIDE 98

Base Information

• Chemical Name: N-PHTHALOYL-DL-GLUTAMIC ANHYDRIDE 98
• CAS No.: 3343-28-0
• Deprecated CAS: 3085-92-5,53602-85-0
• Molecular Formula: C₁₃H₉NO₅
• Molecular Weight: 259.218
• Hs Code.: 2934999090
• European Community (EC) Number: 222-088-1
• NSC Number: 120846,9986
• UNII: 3U6J97P1G8
• DSSTox Substance ID: DTXSID20863154
• Nikkaji Number: J75.650D
• Wikidata: Q27258041
• ChEMBL ID: CHEMBL72541
• Mol file: 3343-28-0.mol

Synonyms:2-(tetrahydro-2,6-dioxo-2h-pyran-3-yl)-1h-isoindole-3(2h)-dione;2-(Tetrahydro-2,6-dioxopyran-3-yl)isoin-dole-1,3(2H)-dione;2-phthalimidoglutaricacidanhydride;2-phthalimido-glutaricanhydrid;4-phthalimidoglutaricanhydride;alpha-phthalimidoglutaricanhydride;dihydro-2-phthalimido-2h-pyran-6(3h)-dione;N-PHTHALOYL-DL-GLUTAMIC ANHYDRIDE 98

Chemical Property of N-PHTHALOYL-DL-GLUTAMIC ANHYDRIDE 98

Chemical Property:

• Vapor Pressure: 1.48E-09mmHg at 25°C
• Melting Point: 197-201 °C(lit.)
• Refractive Index: 1.5880 (estimate)
• Boiling Point: 484.8°Cat760mmHg
• PKA: -2.60±0.20(Predicted)
• Flash Point: 247°C
• PSA: 80.75000
• Density: 1.554g/cm³
• LogP: 0.45270
• Solubility.: soluble in Dioxane
• XLogP3: 0.9
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 1
• Exact Mass: 259.04807239
• Heavy Atom Count: 19
• Complexity: 448

Purity/Quality:

98%,99%, ^*data from raw suppliers

N-Phthaloyl-DL-glutamic Anhydride ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xn
• Statements: 20/21/22-36/37/38-40
• Safety Statements: 23-26-36/37/39-45

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CC(=O)OC(=O)C1N2C(=O)C3=CC=CC=C3C2=O

Technology Process of N-PHTHALOYL-DL-GLUTAMIC ANHYDRIDE 98

There total 6 articles about N-PHTHALOYL-DL-GLUTAMIC ANHYDRIDE 98 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

N-phthalylglutamic acid (6349-98-0,2301-52-2) → N-phthaloylglutamic acid anhydride (3343-28-0,3085-92-5)

Guidance literature:

With acetic anhydride; for 0.25h; Reflux;

DOI:10.1016/j.molstruc.2020.128600

Reference yield:

phthalic anhydride (85-44-9) + L-glutamic acid (56-86-0,21675-62-7,23009-64-5,25104-13-6,84960-48-5,25513-46-6) → N-phthaloylglutamic acid anhydride (3343-28-0,3085-92-5)

Guidance literature:

With pyridine; anschliessendes Erhitzen mit Acetanhydrid;

DOI:10.1021/ja01548a036 DOI:10.1039/jr9490003315

Reference yield:

acetic anhydride (108-24-7) → N-phthaloylglutamic acid anhydride (3343-28-0,3085-92-5)

Guidance literature:

With xylene;

DOI:10.1021/ja01162a031

upstream raw materials:

phthalic anhydride

L-glutamic acid

N-(2-Carboxy-benzoyl)-L-glutaminsaeure

acetic anhydride

Downstream raw materials:

N-(2,6-dioxo-1-phenyl-piperidin-3-yl)-phthalimide

S-benzyl-N-(N,N-phthaloyl-γ-glutamyl)-penicillamine

N-[S-benzyl-N-(N,N-phthaloyl-γ-glutamyl)-penicillaminyl]-glycin-ethyl ester

N⁵-(4-carboxy-phenyl)-N²,N²-phthaloyl-glutamine

Refernces

• 1、 Galin,Sakhautdinov,Lakeev,Egorov,Fatykhov,Maidanova. "Sulfur ylides 13. Synthesis and intramolecular cyclization of keto-stabilized sulfur ylides". . p. 2867 - 2872. Retrieved 2007/10/03.
• 2、 Echavarren, Antonio M.,Castano, Ana M.. "Synthesis of 3-methylaspartic acids by ring-contraction of a nickelacycle derived from glutamic anhydride". . p. 2369 - 2378. Retrieved 2007/10/02.