2,4,6-trichlorophenyl chlorosulfate

Base Information

• Chemical Name: 2,4,6-trichlorophenyl chlorosulfate
• CAS No.: 18997-14-3
• Molecular Formula: C₆H₂Cl₄O₃S
• Molecular Weight: 295.958
• Mol file: 18997-14-3.mol

Synonyms:2,4,6-trichlorophenyl chlorosulfate

Chemical Property of 2,4,6-trichlorophenyl chlorosulfate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,4,6-trichlorophenyl chlorosulfate

There total 2 articles about 2,4,6-trichlorophenyl chlorosulfate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

2,4,6-Trichlorophenol (88-06-2,67471-29-8) → 2,4,6-trichlorophenyl chlorosulfate (18997-14-3)

Guidance literature:

With pyridine; sulfuryl dichloride; In diethyl ether; at -78 - 20 ℃; Inert atmosphere;

DOI:10.1021/acs.orglett.5b01540

Reference yield:

→ 2,4,6-trichlorophenyl chlorosulfate (18997-14-3)

Guidance literature:

Na-Salz v. 2,4,6-Trichlorphenol/Toluol, Sulfurylchlorid/<5grad;

Reference yield: 74.0%

2,4,6-trichlorophenyl chlorosulfate (18997-14-3) + pyridin-2-ylzinc(ll) bromide (81745-83-7) → 2,4,6-trichlorophenyl pyridine-2-sulfonate

Guidance literature:

In tetrahydrofuran; 2-methyltetrahydrofuran; hexane; at 0 - 20 ℃; for 2h; Inert atmosphere;

DOI:10.1021/acs.orglett.5b01540

upstream raw materials:

2,4,6-Trichlorophenol

Downstream raw materials:

Sulfuric acid 2,4,6-trichlorophenyl 2,2,2-trichloroethyl ester

Refernces

• 1、 Colombe, James R.,Debergh, J. Robb,Buchwald, Stephen L.. "Synthesis of Heteroaryl Sulfonamides from Organozinc Reagents and 2,4,6-Trichlorophenyl Chlorosulfate". supporting information. p. 3170 - 3173. Retrieved 2015/06/30.