C₃₃H₃₄ClN₄O₁₃P

Base Information

• Chemical Name: C₃₃H₃₄ClN₄O₁₃P
• CAS No.: 69940-70-1
• Molecular Formula: C₃₃H₃₄ClN₄O₁₃P
• Molecular Weight: 761.079
• Mol file: 69940-70-1.mol

Synonyms:C₃₃H₃₄ClN₄O₁₃P

Chemical Property of C₃₃H₃₄ClN₄O₁₃P

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of C₃₃H₃₄ClN₄O₁₃P

There total 11 articles about C₃₃H₃₄ClN₄O₁₃P which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5'-O-(4-4'-dimethoxytrityl)thymidine (40615-39-2) → C33H34ClN4O13P (69940-70-1)

Guidance literature:

Multi-step reaction with 4 steps

1: pyridine / 1 h / 20 °C

2: benzenesulfonic acid / CHCl₃; methanol / 0.17 h / 0 °C

3: 88 percent / 1-(2,4,6-triisopropylbenzenesulfonyl)-3-nitro-1,2,4-triazole / pyridine / 3 h / 20 °C

4: benzenesulfonic acid / CHCl₃; methanol / 0.25 h / 0 °C

With 1-(2,4,6-triisopropylbenzenesulfonyl)-3-nitro-1,2,4-triazole; benzenesulfonic acid; In pyridine; methanol; chloroform;

DOI:10.1002/hlca.19820650803

Reference yield:

thymidine (50-89-5,28854-96-8,3545-96-8,50-88-4) → C33H34ClN4O13P (69940-70-1)

Guidance literature:

Multi-step reaction with 5 steps

1: 94 percent / 1.) pyridine, 0 deg C, 16 h, 2.) pyridine, CH₃OH, 20 deg C, 1 h

2: pyridine / 1 h / 20 °C

3: benzenesulfonic acid / CHCl₃; methanol / 0.17 h / 0 °C

4: 88 percent / 1-(2,4,6-triisopropylbenzenesulfonyl)-3-nitro-1,2,4-triazole / pyridine / 3 h / 20 °C

5: benzenesulfonic acid / CHCl₃; methanol / 0.25 h / 0 °C

With 1-(2,4,6-triisopropylbenzenesulfonyl)-3-nitro-1,2,4-triazole; benzenesulfonic acid; In pyridine; methanol; chloroform;

DOI:10.1002/hlca.19820650803

Reference yield:

C54H52ClN4O15P (81187-04-4) → C33H34ClN4O13P (69940-70-1)

Guidance literature:

With benzenesulfonic acid; In methanol; chloroform; at 0 ℃; for 0.25h; Yield given;

DOI:10.1002/hlca.19820650803

upstream raw materials:

C₅₄H₅₂ClN₄O₁₅P

2-chlorophenyl 5'-O-(4,4'-dimethoxytrityl)thymidin-3'-yl phosphate

5'-O-(dimethoxytrityl)thymidine 3'-(o-chlorophenyl β-cyanoethyl phosphate)

2-chlorophenyl phosphordi(1H-1-[1,2,4]triazolide)

Refernces