Technology Process of 4-[3-(butylureido)benzoyl]-1-methylpiperidine
There total 7 articles about 4-[3-(butylureido)benzoyl]-1-methylpiperidine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
poly(4-vinyl pyridine);
In
tetrahydrofuran;
for 240h;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / DMF (N,N-dimethyl-formamide) / 63 h
2.1: methyllithium; tert.-butyl lithium / tetrahydrofuran; pentane / 0.92 h / -78 °C
2.2: 21 h / -78 - 20 °C
3.1: hydrogenchloride / water / 1.75 h / Heating / reflux
3.2: 1 h
4.1: poly(4-vinyl pyridine) / tetrahydrofuran / 240 h
With
hydrogenchloride; poly(4-vinyl pyridine); methyllithium; tert.-butyl lithium; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine;
In
tetrahydrofuran; DMF (N,N-dimethyl-formamide); water; pentane;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: hydrogen / palladium 10% on activated carbon / water / 18 h / 20 °C / 3102.97 Torr
2.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / DMF (N,N-dimethyl-formamide) / 63 h
3.1: methyllithium; tert.-butyl lithium / tetrahydrofuran; pentane / 0.92 h / -78 °C
3.2: 21 h / -78 - 20 °C
4.1: hydrogenchloride / water / 1.75 h / Heating / reflux
4.2: 1 h
5.1: poly(4-vinyl pyridine) / tetrahydrofuran / 240 h
With
hydrogenchloride; poly(4-vinyl pyridine); methyllithium; hydrogen; tert.-butyl lithium; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine;
palladium 10% on activated carbon;
In
tetrahydrofuran; DMF (N,N-dimethyl-formamide); water; pentane;