Technology Process of C12H14ClN3O
There total 7 articles about C12H14ClN3O which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
oxalyl dichloride;
In
dichloromethane;
at 20 ℃;
for 1h;
Inert atmosphere;
DOI:10.1021/ol501058a
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: sodium hydride / mineral oil; dimethyl sulfoxide; tetrahydrofuran / 1 h / 20 °C / Inert atmosphere
1.2: 22 h / Inert atmosphere
2.1: lithium chloride / dimethyl sulfoxide / 6 h / 140 °C / Inert atmosphere
3.1: lithium chloride; potassium borohydride / tetrahydrofuran / 23 h / Inert atmosphere; Reflux
4.1: triethylamine; dmap / dichloromethane / 20 h / 20 °C / Inert atmosphere
5.1: sodium azide; tetra-(n-butyl)ammonium iodide / N,N-dimethyl-formamide / 24 h / 40 °C / Inert atmosphere
6.1: sodium hydroxide; water / ethanol / 4 h / 85 °C / Inert atmosphere
7.1: oxalyl dichloride / dichloromethane / 1 h / 20 °C / Inert atmosphere
With
dmap; sodium azide; potassium borohydride; oxalyl dichloride; water; tetra-(n-butyl)ammonium iodide; sodium hydride; triethylamine; lithium chloride; sodium hydroxide;
In
tetrahydrofuran; ethanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; mineral oil;
DOI:10.1021/ol501058a
- Guidance literature:
-
Multi-step reaction with 5 steps
1: lithium chloride; potassium borohydride / tetrahydrofuran / 23 h / Inert atmosphere; Reflux
2: triethylamine; dmap / dichloromethane / 20 h / 20 °C / Inert atmosphere
3: sodium azide; tetra-(n-butyl)ammonium iodide / N,N-dimethyl-formamide / 24 h / 40 °C / Inert atmosphere
4: sodium hydroxide; water / ethanol / 4 h / 85 °C / Inert atmosphere
5: oxalyl dichloride / dichloromethane / 1 h / 20 °C / Inert atmosphere
With
dmap; sodium azide; potassium borohydride; oxalyl dichloride; water; tetra-(n-butyl)ammonium iodide; triethylamine; lithium chloride; sodium hydroxide;
In
tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ol501058a