Nalidixic acid sodium salt

Base Information

• Chemical Name: Nalidixic acid sodium salt
• CAS No.: 3374-05-8
• Molecular Formula: C12H12 N2 O3 . Na
• Molecular Weight: 254.221
• Hs Code.: 29339900
• European Community (EC) Number: 222-159-7
• UNII: Y7NU182221
• DSSTox Substance ID: DTXSID001017230
• Nikkaji Number: J7.725I
• Wikidata: Q27294357
• ChEMBL ID: CHEMBL1255939
• Mol file: 3374-05-8.mol

Synonyms:Acid, Nalidixic;Anhydrous, Nalidixate Sodium;Nalidixate Sodium;Nalidixate Sodium Anhydrous;Nalidixic Acid;Nalidixin;Nevigramon;Sodium Anhydrous, Nalidixate;Sodium Nalidixic Acid, Anhydrous;Sodium Nalidixic Acid, Monohydrate;Sodium, Nalidixate

Chemical Property of Nalidixic acid sodium salt

Chemical Property:

• Appearance/Colour: white to off-white powder
• Vapor Pressure: 1.45E-07mmHg at 25°C
• Melting Point: >280℃
• Boiling Point: 413.1°Cat760mmHg
• Flash Point: 203.6°C
• PSA: 75.02000
• Density: 1.331g/cm³
• LogP: 0.08830
• Storage Temp.: 2-8°C
• Solubility.: H2O: 50 mg/mL, clear, faintly yellow
• Water Solubility.: Soluble at 50mg/ml in water
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 2
• Exact Mass: 254.06673650
• Heavy Atom Count: 18
• Complexity: 384

Purity/Quality:

98%,99%, ^*data from raw suppliers

Nalidixic acid sodium salt ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xn
• Statements: 42/43
• Safety Statements: 22-36/37-45

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCN1C=C(C(=O)C2=C1N=C(C=C2)C)C(=O)[O-].[Na+]
• Uses: anesthetic (local) Nalidixic acid sodium salt is an antibacterial agent, which is inhibitor of bacterial DNA polymerase & avian myeloblastoma virus reverse transcriptase. The compound inhibits nucleic acid and protein synthesis in Saccharomyces cerevisiae.

Technology Process of Nalidixic acid sodium salt

There total 1 articles about Nalidixic acid sodium salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

nalidixic Acid (389-08-2) → nalidixic acid, sodium salt (3374-05-8)

Guidance literature:

With sodium hydroxide; In water; pH=8.5; Reagent/catalyst;

DOI:10.1007/s10973-018-7042-0

Reference yield: 70.5%

nalidixic acid, sodium salt (3374-05-8) + <6R-<6α,7β(Z)>>-7-<<(2-tritylamino-4-thiazolyl)(methoxyimino)acetyl>amino>-3-(iodomethyl)-8-oxo-5-thia-1-azabicyclo<4.2.0>oct-2-ene-2-carboxylic acid tert-butyl ester (105514-47-4) → 1-Ethyl-7-methyl-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-carboxylic acid (6R,7R)-2-tert-butoxycarbonyl-7-{2-[(Z)-methoxyimino]-2-[2-(trityl-amino)-thiazol-4-yl]-acetylamino}-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-en-3-ylmethyl ester (115653-76-4)

Guidance literature:

In N,N-dimethyl-formamide; for 6h;

DOI:10.1021/jm00163a013

Reference yield: 55.0%

ethanol (64-17-5) + nalidixic acid, sodium salt (3374-05-8) → ethyl 1-ethyl-7-methyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylate (33331-59-8)

Guidance literature:

With toluene-4-sulfonic acid; In chloroform; Dean-Stark;

DOI:10.1021/om300424w

upstream raw materials:

nalidixic Acid

Downstream raw materials:

<2R-(2α,6α,7β)>-3-<<<(1-ethyl-1,4-dihydro-7-methyl-4-oxo-1,8-naphthyridin-3-yl)carbonyl>oxy>methyl>-8-oxo-7-<(phenoxyacetyl)amino>-5-thia-1-azabicyclo<4.2.0>oct-3-ene-2-carboxylic acid

<2R-(2α,6α,7β)>-3-<<<(1-ethyl-1,4-dihydro-7-methyl-4-oxo-1,8-naphthyridin-3-yl)carbonyl>oxy>methyl>-8-oxo-7-<(phenoxyacetyl)amino>-5-thia-1-azabicyclo<4.2.0>oct-3-ene-2-carboxylic acid (4-nitrophenyl)methyl ester

(6R-trans)-3-<<<(1-ethyl-1,4-dihydro-7-methyl-4-oxo-1,8-naphthyridin-3-yl)carbonyl>oxy>methyl>-8-oxo-7-<(phenoxyacetyl)amino>-5-thia-1-azabicyclo<4.2.0>oct-2-ene-2-carboxylic acid (4-nitrophenyl)methyl ester

1-Ethyl-7-methyl-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-carboxylic acid (6R,7R)-2-tert-butoxycarbonyl-7-{2-[(Z)-methoxyimino]-2-[2-(trityl-amino)-thiazol-4-yl]-acetylamino}-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-en-3-ylmethyl ester

Refernces

• 1、 Dobies Návia, Marcos Vinícius,Alves Gálico, Diogo,Junior Caires, Flávio,Marques Luiz, José,Spezia Nunes, Ronaldo. "Synthesis, thermal behavior, and spectroscopic study of the solid nalidixate of selected light trivalent lanthanides". . p. 1717 - 1727. Retrieved 2018.