Tramazoline hydrochloride monohydrate

Base Information

• Chemical Name: Tramazoline hydrochloride monohydrate
• CAS No.: 74195-73-6
• Molecular Formula: C₁₃H₁₇N₃•ClH•H₂O
• Molecular Weight: 251.759
• European Community (EC) Number: 850-033-7
• UNII: 9DF5N42U1U
• DSSTox Substance ID: DTXSID30225188
• Wikidata: Q27272398
• Mol file: 74195-73-6.mol

Synonyms:2-(5,6,7,8-tetrahydro-1-naphthylamino)-2-imidazoline;Biciron;Bisolnasal;Ellatun;KB 227;Rhinospray;Spray-Tish;tramazoline;tramazoline hydrochloride;tramazoline monohydrochloride

Chemical Property of Tramazoline hydrochloride monohydrate

Chemical Property:

• PSA: 45.65000
• LogP: 2.51160
• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 269.1294900
• Heavy Atom Count: 18
• Complexity: 274

Purity/Quality:

99% ^*data from raw suppliers

Tramazoline hydrochloride monohydrate European Pharmacopoeia (EP) Reference Standard ^*data from reagent suppliers

Safty Information:

• Pictogram(s): 3
• Hazard Codes: 3

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CCC2=C(C1)C=CC=C2NC3=NCCN3.O.Cl
• Uses: The Monohydrochloride Salt version of Tramazoline (T704800(M)), which is commonly used in nasal spray as a nasal decongestant by acting as an α-adrenergic receptor agonist that inhibits secretion of nasal mucus.

Technology Process of Tramazoline hydrochloride monohydrate

There total 2 articles about Tramazoline hydrochloride monohydrate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ [1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid (53-86-1) + KB 227 (74195-73-6,14008-86-7)

Guidance literature:

Reference yield:

→ fluorobiprofen (5104-49-4) + KB 227 (74195-73-6,14008-86-7)

Guidance literature:

Refernces

• 1、 -. "Pharmaceutical composition for ophthalmic use comprising a nonsteroidal anti-inflammatory and a decongestant drug". . . Retrieved 2008/06/13.