Technology Process of C19H16F2N6O2
There total 7 articles about C19H16F2N6O2 which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
2,6-difluoro-3,5-dimethoxybenzeneamine;
With
potassium hexamethylsilazane;
In
tetrahydrofuran;
at 0 ℃;
for 1h;
C11H8ClN5;
In
tetrahydrofuran; N,N-dimethyl-formamide;
at 0 - 20 ℃;
for 24h;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: hydrogen bromide; acetic acid / 3 h / 40 - 50 °C
2.1: N,N-dimethyl-formamide; trichlorophosphate / 1,2-dichloro-ethane / 3 h / 80 °C
3.1: tetrakis(triphenylphosphine) palladium(0); sodium carbonate / 1,2-dimethoxyethane; water / 2 h / Inert atmosphere; Reflux
4.1: potassium hexamethylsilazane / tetrahydrofuran / 1 h / 0 °C
4.2: 24 h / 0 - 20 °C
With
tetrakis(triphenylphosphine) palladium(0); hydrogen bromide; potassium hexamethylsilazane; sodium carbonate; acetic acid; N,N-dimethyl-formamide; trichlorophosphate;
In
tetrahydrofuran; 1,2-dimethoxyethane; water; 1,2-dichloro-ethane;
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: N,N-dimethyl-formamide; trichlorophosphate / 1,2-dichloro-ethane / 3 h / 80 °C
2.1: potassium hexamethylsilazane / tetrahydrofuran / 1 h / 0 °C
2.2: 24 h / 0 - 20 °C
With
potassium hexamethylsilazane; N,N-dimethyl-formamide; trichlorophosphate;
In
tetrahydrofuran; 1,2-dichloro-ethane;