Technology Process of (2S)-3,3-Diphenylalanine hydrochloride
There total 10 articles about (2S)-3,3-Diphenylalanine hydrochloride which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
lithium hydroxide; tetrabutylammomium bromide; lithium bromide;
In
acetonitrile;
for 8h;
Ambient temperature;
DOI:10.1016/0040-4039(91)80217-T
- Guidance literature:
-
With
hydrogenchloride; hydrogen;
palladium on activated charcoal;
In
tetrahydrofuran;
for 20h;
under 2585.7 Torr;
DOI:10.1016/S0040-4039(00)92070-7
- Guidance literature:
-
Multi-step reaction with 5 steps
1: iPr2NEt / tetrahydrofuran / 1 h / -78 to 0 deg C
2: 1) n-BuLi / 1) THF, -78 deg C, 2) -78 to 0 deg C
3: 1) KHMDS, 2) trisyl azide / 1) THF, -78 deg C, 2) THF, -78 deg C, 2 min
4: LiOH*H2O, 30percent aq. H2O2 / tetrahydrofuran; H2O / 1 h / 0 °C
5: HCl, H2 / 10percent Pd/C / tetrahydrofuran / 20 h / 2585.7 Torr
With
hydrogenchloride; lithium hydroxide; n-butyllithium; 2,4,6-Triisopropylbenzenesulfonyl azide; hydrogen; dihydrogen peroxide; potassium hexamethylsilazane; N-ethyl-N,N-diisopropylamine;
palladium on activated charcoal;
In
tetrahydrofuran; water;
DOI:10.1016/S0040-4039(00)92070-7
