N-(4-AMINOPHENYL)-4-METHYLBENZENESULFONAMIDE

Base Information

• Chemical Name: N-(4-AMINOPHENYL)-4-METHYLBENZENESULFONAMIDE
• CAS No.: 6380-08-1
• Molecular Formula: C13H14N2O2S
• Molecular Weight: 262.332
• Hs Code.: 2935009090
• Mol file: 6380-08-1.mol

Synonyms:p-Toluenesulfonanilide,4'-amino- (7CI,8CI);N-(4-Aminophenyl)-4-methylbenzenesulfonamide;N-(4-Aminophenyl)-p-toluenesulfonamide;N-(4'-Aminophenyl)-4-methylbenzenesulfonamide;N-(p-Aminophenyl)-p-toluenesulfonamide;

Chemical Property of N-(4-AMINOPHENYL)-4-METHYLBENZENESULFONAMIDE

Chemical Property:

• Vapor Pressure: 2.03E-08mmHg at 25°C
• Melting Point: 183-185 °C(lit.)
• Refractive Index: 1.653
• Boiling Point: 453.7 °C at 760 mmHg
• PKA: 10.43±0.10(Predicted)
• Flash Point: 228.2 °C
• PSA: 80.57000
• Density: 1.33 g/cm³
• LogP: 4.11300

Purity/Quality:

98%min ^*data from raw suppliers

N-(4-Aminophenyl)-4-methylbenzenesulfonamide 99% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37/39

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Uses: N-(4-Aminophenyl)-4-methylbenzenesulfonamide may be used in the preparation of following compounds:4-methyl-N-[4-[3-(2-naphthyl)imidazo[1,2-a]pyrazine-8-yl]aminophenyl]benzenesulfonamide 4-methyl-N-[4-[2-(2-naphthyl)imidazo[1,2-a]pyrazine-8-yl]aminophenyl]benzenesulfonamide2- and 3-substituted 8-amino imidazo[1,2-a]pyrazines

Technology Process of N-(4-AMINOPHENYL)-4-METHYLBENZENESULFONAMIDE

There total 12 articles about N-(4-AMINOPHENYL)-4-METHYLBENZENESULFONAMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

N-(4-nitrophenyl)-4-methylbenzenesulfonamide (734-25-8) → N-(4-aminophenyl)-4-methylbenzenesulfonamide (6380-08-1)

Guidance literature:

With samarium; 1,1’-di-n-octyl-4,4’-bipyridinium dibromide; In methanol; at 20 ℃; for 10h;

DOI:10.1021/jo005666q

Reference yield: 93.0%

p-toluenesulfonyl fluoride (455-16-3) + 1,4-phenylenediamine (106-50-3) → N-(4-aminophenyl)-4-methylbenzenesulfonamide (6380-08-1)

Guidance literature:

With 1,1,3,3-Tetramethyldisiloxane; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; In dimethyl sulfoxide; at 25 ℃; for 24h; Sealed tube;

DOI:10.1002/anie.202013976

Reference yield: 50.0%

toluene-4-sulfonic acid (104-15-4) + 1,4-phenylenediamine (106-50-3) → N-(4-aminophenyl)-4-methylbenzenesulfonamide (6380-08-1)

Guidance literature:

With triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In dichloromethane; at 20 ℃; for 5h;

DOI:10.1016/j.bmc.2020.115596

upstream raw materials:

N-(4-nitrophenyl)-4-methylbenzenesulfonamide

p-toluenesulfonyl chloride

1,4-phenylenediamine

4-toluenesulfonyl azide

Downstream raw materials:

N-[4-(4-Methylbenzene)sulfonylaminophenyl]-(2-chloro-5-nitrophenyl)carboxamide

1,4-phenylenediamine

Refernces

• 1、 Wei, Mingjie,Liang, Dacheng,Cao, Xiaohui,Luo, Wenjun,Ma, Guojian,Liu, Zeyuan,Li, Le. "A Broad-Spectrum Catalytic Amidation of Sulfonyl Fluorides and Fluorosulfates**". supporting information. p. 7397 - 7404. Retrieved 2021/02/16.
• 2、 -. "Method for preparing P-phenylenediamine from aniline". . . Retrieved 2020/07/21.