C₁₈H₂₇NO₅

Base Information

• Chemical Name: C₁₈H₂₇NO₅
• CAS No.: 1312687-84-5
• Molecular Formula: C₁₈H₂₇NO₅
• Molecular Weight: 337.416
• Mol file: 1312687-84-5.mol

Synonyms:C₁₈H₂₇NO₅

Chemical Property of C₁₈H₂₇NO₅

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₈H₂₇NO₅

There total 4 articles about C₁₈H₂₇NO₅ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.5%

C20H29NO6 (959279-50-6) → C18H27NO5 (1312687-84-5)

Guidance literature:

With Rhodotorula mucilaginosa DQ₈₃₂₁₉₈; at 28 ℃; for 12h; pH=6; enantioselective reaction; Microbiological reaction; phosphate-citric acid buffer;

DOI:10.1080/00397911.2010.505699

Reference yield:

p-hydroxyphenethyl alcohol (501-94-0) → C18H27NO5 (1312687-84-5)

Guidance literature:

Multi-step reaction with 4 steps

1: potassium carbonate / acetonitrile / 6 h / Reflux

2: methanol / 7 h / 20 °C

3: pyridine; triethylamine / 20 °C

4: Rhodotorula mucilaginosa DQ₈₃₂₁₉₈ / 12 h / 28 °C / pH 6 / Microbiological reaction; phosphate-citric acid buffer

With pyridine; potassium carbonate; triethylamine; In methanol; acetonitrile;

DOI:10.1080/00397911.2010.505699

Reference yield:

1-[4-(2-hydroxyethyl)phenoxy]-2,3-epoxypropane (104857-48-9) → C18H27NO5 (1312687-84-5)

Guidance literature:

Multi-step reaction with 3 steps

1: methanol / 7 h / 20 °C

2: pyridine; triethylamine / 20 °C

3: Rhodotorula mucilaginosa DQ₈₃₂₁₉₈ / 12 h / 28 °C / pH 6 / Microbiological reaction; phosphate-citric acid buffer

With pyridine; triethylamine; In methanol;

DOI:10.1080/00397911.2010.505699

upstream raw materials:

C₂₀H₂₉NO₆

p-hydroxyphenethyl alcohol

1-[4-(2-hydroxyethyl)phenoxy]-2,3-epoxypropane

(+/-)-O-Demethylmetoprolol

Downstream raw materials:

(-)-O-Demethylmetoprolol

(5S)-2-(4-((3-isopropyl-2-phenyloxazolidin)-5-methoxy)phenyl)-4-ethanol

(-)-Betaxolol

Refernces