4-fluoro-3-iodobenzoyl chloride

Base Information

• Chemical Name: 4-fluoro-3-iodobenzoyl chloride
• CAS No.: 1170669-90-5
• Molecular Formula: C₇H₃ClFIO
• Molecular Weight: 284.456
• Mol file: 1170669-90-5.mol

Synonyms:4-fluoro-3-iodobenzoyl chloride

Chemical Property of 4-fluoro-3-iodobenzoyl chloride

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 4-fluoro-3-iodobenzoyl chloride

There total 2 articles about 4-fluoro-3-iodobenzoyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-iodo-4-fluorobenzoic acid (403-18-9) → 4-fluoro-3-iodobenzoyl chloride (1170669-90-5)

Guidance literature:

With thionyl chloride; for 27h; Reflux; Inert atmosphere;

DOI:10.1039/b820235d

Reference yield:

3-amino-4-fluorobenzoic acid (2365-85-7) → 4-fluoro-3-iodobenzoyl chloride (1170669-90-5)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium nitrite; hydrogenchloride / water / 0.5 h / -15 - -10 °C

1.2: 3 h / -5 - 20 °C

2.1: N,N-dimethyl-formamide; oxalyl dichloride / dichloromethane / 17.5 h / 0 - 20 °C / Inert atmosphere

With hydrogenchloride; oxalyl dichloride; N,N-dimethyl-formamide; sodium nitrite; In dichloromethane; water;

DOI:10.1021/ml500423v

Reference yield:

2,3,5,6-tetraflourophenol (769-39-1,85303-67-9) + 4-fluoro-3-iodobenzoyl chloride (1170669-90-5) → 2,3,5,6-tetrafluorophenyl 4-fluoro-3-iodobenzoate

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 4h; Inert atmosphere;

DOI:10.1021/ml500423v

upstream raw materials:

3-iodo-4-fluorobenzoic acid

3-amino-4-fluorobenzoic acid

Downstream raw materials:

N-4-fluoro-3-iodobenzoylbutanimidic ethyl ester

methyl 4-fluoro-3-iodobenzoate

Refernces

• 1、 Liu, Yang,Peng, Xia,Guan, Xiaocong,Lu, Dong,Xi, Yong,Jin, Shiyu,Chen, Hui,Zeng, Limin,Ai, Jing,Geng, Meiyu,Hu, Youhong. "Discovery of novel Ponatinib analogues for reducing KDR activity as potent FGFRs inhibitors". . p. 122 - 132. Retrieved 2016/10/25.