Technology Process of darifenacin hydrochloride
There total 13 articles about darifenacin hydrochloride which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
hydrogenchloride;
In
water; acetone;
at 0 - 30 ℃;
for 12h;
Product distribution / selectivity;
- Guidance literature:
-
Multi-step reaction with 2 steps
1: potassium hydroxide / acetonitrile / 18 h / 40 - 50 °C
2: hydrogenchloride / water; acetone / 12 h / 0 - 30 °C
With
hydrogenchloride; potassium hydroxide;
In
water; acetone; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: sodium tetrahydroborate; sulfuric acid / tetrahydrofuran / 10 h / -5 - 0 °C
2: sodium bromide / acetone / 48 h / Heating / reflux
3: potassium hydroxide / acetonitrile / 18 h / 40 - 50 °C
4: hydrogenchloride / water; acetone / 12 h / 0 - 30 °C
With
hydrogenchloride; potassium hydroxide; sodium tetrahydroborate; sulfuric acid; sodium bromide;
In
tetrahydrofuran; water; acetone; acetonitrile;
