Technology Process of (R)-1-phenylseleno-3-(2',4'-dimethoxyphenyl)-3-phenylpropane
There total 4 articles about (R)-1-phenylseleno-3-(2',4'-dimethoxyphenyl)-3-phenylpropane which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
tributylphosphine;
In
tetrahydrofuran;
for 2h;
DOI:10.1021/ol990961m
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 97 percent / LiAlH4 / tetrahydrofuran; diethyl ether / 0 °C
2: 100 percent / potassium carbonate / acetone / Heating
3: hydrogen / [Rh((R,R)-bdpp)(NBD)]ClO4 / methanol / 168 h / 60006 Torr
4: 81 percent / n-Bu3P / tetrahydrofuran / 2 h
With
lithium aluminium tetrahydride; tributylphosphine; hydrogen; potassium carbonate;
[Rh((R,R)-bdpp)(NBD)]ClO4;
In
tetrahydrofuran; methanol; diethyl ether; acetone;
DOI:10.1021/ol990961m
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 100 percent / potassium carbonate / acetone / Heating
2: hydrogen / [Rh((R,R)-bdpp)(NBD)]ClO4 / methanol / 168 h / 60006 Torr
3: 81 percent / n-Bu3P / tetrahydrofuran / 2 h
With
tributylphosphine; hydrogen; potassium carbonate;
[Rh((R,R)-bdpp)(NBD)]ClO4;
In
tetrahydrofuran; methanol; acetone;
DOI:10.1021/ol990961m