2-O-benzyl-1,3-bis[(1,2-di-O-lauroyl-sn-glycero-3)-phosphoryl]glycerol di(2-cyanoethyl) ester

Base Information

• Chemical Name: 2-O-benzyl-1,3-bis[(1,2-di-O-lauroyl-sn-glycero-3)-phosphoryl]glycerol di(2-cyanoethyl) ester
• CAS No.: 688021-81-0
• Molecular Formula: C₇₀H₁₂₂N₂O₁₇P₂
• Molecular Weight: 1325.69
• Mol file: 688021-81-0.mol

Synonyms:2-O-benzyl-1,3-bis[(1,2-di-O-lauroyl-sn-glycero-3)-phosphoryl]glycerol di(2-cyanoethyl) ester

Chemical Property of 2-O-benzyl-1,3-bis[(1,2-di-O-lauroyl-sn-glycero-3)-phosphoryl]glycerol di(2-cyanoethyl) ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-O-benzyl-1,3-bis[(1,2-di-O-lauroyl-sn-glycero-3)-phosphoryl]glycerol di(2-cyanoethyl) ester

There total 2 articles about 2-O-benzyl-1,3-bis[(1,2-di-O-lauroyl-sn-glycero-3)-phosphoryl]glycerol di(2-cyanoethyl) ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Dodecanoic acid (R)-2-[(2-cyano-ethoxy)-diisopropylamino-phosphanyloxy]-1-dodecanoyloxymethyl-ethyl ester + 2-O-benzylglycerol (14690-00-7) → 2-O-benzyl-1,3-bis[(1,2-di-O-lauroyl-sn-glycero-3)-phosphoryl]glycerol di(2-cyanoethyl) ester (688021-81-0)

Guidance literature:

Dodecanoic acid (R)-2-[(2-cyano-ethoxy)-diisopropylamino-phosphanyloxy]-1-dodecanoyloxymethyl-ethyl ester; 2-O-benzylglycerol; With 1H-tetrazole; In dichloromethane; acetonitrile; at 20 ℃; for 3h;

With dihydrogen peroxide; In dichloromethane; acetonitrile; at -40 - 20 ℃; for 2.25h;

DOI:10.1016/j.tet.2006.04.071

Reference yield:

dodecanoic acid 1,1'-[(1S)-1-(hydroxymethyl)-1,2-ethanediyl]ester (17598-94-6,59540-17-9,61475-84-1,60562-15-4) → 2-O-benzyl-1,3-bis[(1,2-di-O-lauroyl-sn-glycero-3)-phosphoryl]glycerol di(2-cyanoethyl) ester (688021-81-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: ethyldiisopropylamine / CH₂Cl₂ / 1 h / 20 °C

2.1: 1H-tetrazole / CH₂Cl₂; acetonitrile / 3 h / 20 °C

2.2: hydrogen peroxide / CH₂Cl₂; acetonitrile / 2.25 h / -40 - 20 °C

With 1H-tetrazole; N-ethyl-N,N-diisopropylamine; In dichloromethane; acetonitrile;

DOI:10.1016/j.tet.2006.04.071

Reference yield: 89.0%

2-O-benzyl-1,3-bis[(1,2-di-O-lauroyl-sn-glycero-3)-phosphoryl]glycerol di(2-cyanoethyl) ester (688021-81-0) → 1,3-bis[(1,2-di-O-lauroyl-sn-glycero-3)-phosphoryl]-2-O-benzylglycerol diammonium salt

Guidance literature:

2-O-benzyl-1,3-bis[(1,2-di-O-lauroyl-sn-glycero-3)-phosphoryl]glycerol di(2-cyanoethyl) ester; With triethylamine; In water; acetonitrile;

With ammonium hydroxide;

DOI:10.1016/j.tet.2006.04.071

upstream raw materials:

2-O-benzylglycerol

dodecanoic acid 1,1'-[(1S)-1-(hydroxymethyl)-1,2-ethanediyl]ester

Refernces