(+)-(11S,12R)-erythro-mefloquine-(R)-mosher amide

Base Information

• Chemical Name: (+)-(11S,12R)-erythro-mefloquine-(R)-mosher amide
• CAS No.: 1443837-22-6
• Molecular Formula: C₂₇H₂₃F₉N₂O₃
• Molecular Weight: 594.477
• Mol file: 1443837-22-6.mol

Synonyms:(+)-(11S,12R)-erythro-mefloquine-(R)-mosher amide

Chemical Property of (+)-(11S,12R)-erythro-mefloquine-(R)-mosher amide

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of (+)-(11S,12R)-erythro-mefloquine-(R)-mosher amide

There total 3 articles about (+)-(11S,12R)-erythro-mefloquine-(R)-mosher amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

(S)-(+)-2-methoxy-2-trifluoromethyl-2-phenylacetyl chloride (39637-99-5,20445-33-4) + (R)-2-((S)-(2,8-bis(trifluoromethyl)quinolin-4-yl)(hydroxy)methyl)piperidin-1-ium chloride (68682-28-0) → (+)-(11S,12R)-erythro-mefloquine-(R)-mosher amide (1443837-22-6)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 - 20 ℃; for 2h; Inert atmosphere;

DOI:10.1002/anie.201300258

Reference yield: 41.0%

(S)-(+)-2-methoxy-2-trifluoromethyl-2-phenylacetyl chloride (39637-99-5,20445-33-4) + rac-erythro-mefloquine → (+)-(11S,12R)-erythro-mefloquine-(R)-mosher amide (1443837-22-6) + (+)-(11R,12S)-erythro-mefloquine-(R)-mosher amide (1443837-23-7)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 2h;

DOI:10.1002/anie.201300258

Reference yield:

(S)-(+)-2-methoxy-2-trifluoromethyl-2-phenylacetyl chloride (39637-99-5,20445-33-4) + mefloquine (49752-90-1,51688-68-7,51742-87-1,53230-10-7,58737-31-8,68682-27-9,147368-41-0,148690-80-6) → (+)-(11S,12R)-erythro-mefloquine-(R)-mosher amide (1443837-22-6)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 - 20 ℃; for 2h; Inert atmosphere;

DOI:10.1002/anie.201300258

upstream raw materials:

(S)-(+)-2-methoxy-2-trifluoromethyl-2-phenylacetyl chloride

(R)-2-((S)-(2,8-bis(trifluoromethyl)quinolin-4-yl)(hydroxy)methyl)piperidin-1-ium chloride

mefloquine

Refernces