Ethyl 9H-xanthene-9-carboxylate

Base Information

• Chemical Name: Ethyl 9H-xanthene-9-carboxylate
• CAS No.: 7401-03-8
• Molecular Formula: C16H14O3
• Molecular Weight: 254.285
• Hs Code.: 2932999099
• Mol file: 7401-03-8.mol

Synonyms:9-Xanthenecarboxylicacid, ethyl- (3CI);Xanthene-9-carboxylic acid, ethyl ester (8CI);Ethylxanthene-9-carboxylate;NSC 37339;

Chemical Property of Ethyl 9H-xanthene-9-carboxylate

Chemical Property:

• Vapor Pressure: 5.82E-05mmHg at 25°C
• Melting Point: 66-68 °C
• Refractive Index: 1.586
• Boiling Point: 629.302 °C at 760 mmHg
• Flash Point: 348.398 °C
• PSA: 35.53000
• Density: 1.144 g/cm³
• LogP: 3.48730

Purity/Quality:

99% ^*data from raw suppliers

ETHYL 9H-XANTHENE-9-CARBOXYLATE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Ethyl 9H-xanthene-9-carboxylate

There total 4 articles about Ethyl 9H-xanthene-9-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

ethanol (64-17-5) + xanthene-9-carboxylic acid (82-07-5) → xanthene-9-carboxylic acid ethyl ester (7401-03-8)

Guidance literature:

With sulfuric acid; at 95 - 100 ℃; for 24h;

DOI:10.1002/ejoc.202100913

Reference yield:

xanth-9-one (90-47-1) → xanthene-9-carboxylic acid ethyl ester (7401-03-8)

Guidance literature:

Multi-step reaction with 3 steps

1.1: dimethylsulfide borane complex / tetrahydrofuran / 1 h / 75 - 80 °C / Inert atmosphere

2.1: N,N,N,N,-tetramethylethylenediamine; n-butyllithium / tetrahydrofuran; hexane / 0.17 h / -78 °C

2.2: 0.33 h / -78 - 20 °C

3.1: sulfuric acid / 24 h / 95 - 100 °C

With n-butyllithium; N,N,N,N,-tetramethylethylenediamine; dimethylsulfide borane complex; sulfuric acid; In tetrahydrofuran; hexane;

DOI:10.1002/ejoc.202100913

Reference yield:

xanthene (92-83-1) → xanthene-9-carboxylic acid ethyl ester (7401-03-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: N,N,N,N,-tetramethylethylenediamine; n-butyllithium / tetrahydrofuran; hexane / 0.17 h / -78 °C

1.2: 0.33 h / -78 - 20 °C

2.1: sulfuric acid / 24 h / 95 - 100 °C

With n-butyllithium; N,N,N,N,-tetramethylethylenediamine; sulfuric acid; In tetrahydrofuran; hexane;

DOI:10.1002/ejoc.202100913

upstream raw materials:

ethanol

xanthene-9-carboxylic acid

xanth-9-one

xanthene

Downstream raw materials:

Spiro-2-on

Refernces