Technology Process of 17β-hydroxypregna-4,9(11)-dien-3-one-7α,21-dicarboxylic acid γ-lactone
There total 1 articles about 17β-hydroxypregna-4,9(11)-dien-3-one-7α,21-dicarboxylic acid γ-lactone which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: 77.7 percent / boron trifluoride diethyl etherate; EtOH; isopropanol / acetonitrile / 24 h / -18.4 °C
2.1: potassium acetate; dibromantin / acetone; H2O / -10 °C
3.1: aq. HCl / CH2Cl2 / 2.5 h / 20 °C
4.1: O3/O2 / CH2Cl2; propan-2-ol / 0.17 h / -55 °C
4.2: dimethylsilfide / CH2Cl2; propan-2-ol / 0.83 h / 20 °C
5.1: 0.865 mg / H2O2; KHCO3 / H2O; methanol / 16 h / 20 °C
With
hydrogenchloride; 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; ethanol; boron trifluoride diethyl etherate; dihydrogen peroxide; oxygen; potassium acetate; potassium hydrogencarbonate; ozone; isopropyl alcohol;
In
methanol; dichloromethane; water; isopropyl alcohol; acetone; acetonitrile;
5.1: Baeyer-Villiger oxidation;
DOI:10.1021/ol060503v
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 2.7 g / CH2Cl2; diethyl ether / 0.17 h
2: 71.6 percent / aq. H2O2, (CCl3CO)2O / CH2Cl2 / 1.5 h / below 4 deg C
With
dihydrogen peroxide; trichloroacetic acid anhydride;
In
diethyl ether; dichloromethane;
DOI:10.1002/hlca.19970800220
