trans-4-phenylcyclophosphamide

Base Information

• Chemical Name: trans-4-phenylcyclophosphamide
• CAS No.: 903635-44-9
• Molecular Formula: C₁₃H₁₉Cl₂N₂O₂P
• Molecular Weight: 337.186
• Mol file: 903635-44-9.mol

Synonyms:trans-4-phenylcyclophosphamide

Chemical Property of trans-4-phenylcyclophosphamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of trans-4-phenylcyclophosphamide

There total 2 articles about trans-4-phenylcyclophosphamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N,N-di(2-chloroethyl)amidophosphoric acid dichloride (127-88-8) + 3-amino-3-phenyl-1-propanol (14593-04-5,82769-76-4) → trans-4-phenylcyclophosphamide (903635-44-9) + (2RS,4SR)-2--4-phenyl-2H-1,3,2-oxazaphosphorinane 2-oxide (68208-27-5,68208-28-6,81313-77-1,87154-35-6)

Guidance literature:

With triethylamine; In ethyl acetate; for 72h; Yield given. Yields of byproduct given;

DOI:10.1021/jm00178a005

Reference yield:

→ trans-4-phenylcyclophosphamide (903635-44-9)

Guidance literature:

Aminopropanol 10, Bis(2-chlorethyl)phosphoramid-dichlorid;

Reference yield: 94.0%

trans-4-phenylcyclophosphamide (903635-44-9) → trans-3-chloro-4-phenylcyclophosphamide

Guidance literature:

With sodium hypochlorite; In chloroform; for 168h; Ambient temperature;

DOI:10.1002/jps.2600720622

upstream raw materials:

N,N-di(2-chloroethyl)amidophosphoric acid dichloride

3-amino-3-phenyl-1-propanol

Refernces