N-(Chloroacetyl)-DL-leucine

Base Information

• Chemical Name: N-(Chloroacetyl)-DL-leucine
• CAS No.: 7154-83-8
• Molecular Formula: C8H14ClNO3
• Molecular Weight: 207.657
• European Community (EC) Number: 230-510-0
• NSC Number: 73842,60158
• Mol file: 7154-83-8.mol

Synonyms:7154-83-8;N-(Chloroacetyl)-DL-leucine;CHLOROACETYL-DL-LEUCINE;Chloroac-DL-Leu-OH;EINECS 230-510-0;2-(2-chloroacetamido)-4-methylpentanoic acid;C8-H14-Cl-N-O3;2-[(2-chloroacetyl)amino]-4-methylpentanoic acid;EINECS 211-700-2;Leucine,N-(chloroacetyl)- (9CI);NSC60158;Chloracetyl-D,L-leucin;CHLOROACETYL-D,L-LEUCINE;SCHEMBL11740515;Leucine,N-(chloroacetyl)-(9ci);NSC73842;NSC 60158;NSC 73842;NSC-60158;NSC-73842;AKOS002981693;BETA-D-GLUCOSE-1-C-DPENTAACETATE;FT-0632804;FT-0751295;EN300-34593

Chemical Property of N-(Chloroacetyl)-DL-leucine

Chemical Property:

• Boiling Point: 401.1 °C at 760 mmHg
• Flash Point: 196.4 °C
• PSA: 66.40000
• Density: 1.198 g/cm³
• LogP: 1.23160
• XLogP3: 1.5
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 5
• Exact Mass: 207.0662210
• Heavy Atom Count: 13
• Complexity: 194

Purity/Quality:

98.5% ^*data from raw suppliers

Chloroac-DL-Leu-OH ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)CC(C(=O)O)NC(=O)CCl

Technology Process of N-(Chloroacetyl)-DL-leucine

There total 2 articles about N-(Chloroacetyl)-DL-leucine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

chloroacetyl chloride (79-04-9) + LEUCINE (328-39-2,21675-61-6,25248-98-0,70-45-1) → N-chloroacetyl-D,L-leucine (7154-83-8)

Guidance literature:

Reference yield:

L-leucine (61-90-5,21675-61-6,25248-98-0,70-45-1) + chloroacetyl chloride (79-04-9) → N-chloroacetyl-D,L-leucine (7154-83-8)

Guidance literature:

With sodium hydroxide; chloroacetyl-l-leucine;

Reference yield:

N-chloroacetyl-D,L-leucine (7154-83-8) → L-leucine (61-90-5,21675-61-6,25248-98-0,70-45-1)

Guidance literature:

Hydrolysis_.mit Hilfe eines Enzym-Praeparats aus Schweinenieren;

upstream raw materials:

L-leucine

chloroacetyl chloride

LEUCINE

Downstream raw materials:

glycylleucine

L-leucine

4-Isobutyl-3-[2-(2-oxo-4-phenyl-pyrrolidin-1-yl)-acetyl]-oxazolidin-5-one

N-(2-oxo-4-phenyl-1-pyrrolidinyl)acetyl-D,L-leucine ethyl ester