3-BROMO-4-NITRO (1H)INDAZOLE

Base Information

• Chemical Name: 3-BROMO-4-NITRO (1H)INDAZOLE
• CAS No.: 74209-17-9
• Molecular Formula: C7H4BrN3O2
• Molecular Weight: 242.032
• Hs Code.: 2933998090
• Mol file: 74209-17-9.mol

Synonyms:Indazole,3-bromo-4-nitro- (3CI);3-Bromo-4-nitro-1H-indazole;

Chemical Property of 3-BROMO-4-NITRO (1H)INDAZOLE

Chemical Property:

• Vapor Pressure: 0.0236mmHg at 25°C
• Refractive Index: 1.763
• Boiling Point: 248.9 °C at 760 mmHg
• Flash Point: 104.3 °C
• Density: 1.965 g/cm³
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

99.3% ^*data from raw suppliers

3-Bromo-4-nitro-1H-indazole ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-BROMO-4-NITRO (1H)INDAZOLE

There total 3 articles about 3-BROMO-4-NITRO (1H)INDAZOLE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

nitro-4 indazole (2942-40-7) → 3-bromo-4-nitro-1H-indazole (74209-17-9)

Guidance literature:

With bromine; sodium acetate; acetic acid; In chloroform; at 25 ℃; for 5.5h;

Reference yield:

3-nitro-o-tolylamine (603-83-8) → 3-bromo-4-nitro-1H-indazole (74209-17-9)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium nitrite / water; acetic acid

2: N-Bromosuccinimide / acetonitrile / 1.5 h / Reflux

With N-Bromosuccinimide; sodium nitrite; In water; acetic acid; acetonitrile;

DOI:10.1080/00397911003707212

Reference yield:

→ 3-bromo-4-nitro-1H-indazole (74209-17-9)

Guidance literature:

entspr. Indazol, Brom;

upstream raw materials:

nitro-4 indazole

3-nitro-o-tolylamine

Downstream raw materials:

N-(3-bromo-1H-indazol-4-yl)-4-methyl-benzenesulfonamide

N-(3-bromo-7-ethoxy-1H-indazol-4-yl)-4-methyl-benzenesulfonamide

1-benzyl-3-bromo-4-nitro-1H-indazole

3-bromo-1-((6-isopropylpyridin-2-yl)methyl)-4-nitro-1H-indazole

Refernces

• 1、 -. "FUSED PYRIMIDINE DERIVATIVES HAVING INHIBITORY ACTIVITY ON FMS KINASES". Page/Page column 24. . Retrieved 2014/01/17.
• 2、 Abbassi,Rakib,Bouissane,Hannioui,Khouili,El Malki,Benchidmi,Essassi. "Studies on the reduction of the nitro group in 4-nitroindazoles by anhydrous SnCl2in different alcohols". experimental part. p. 999 - 1005. Retrieved 2011/04/23.