4,4,4-trifluoro-but-2-enal

Base Information

• Chemical Name: 4,4,4-trifluoro-but-2-enal
• CAS No.: 406-88-2
• Molecular Formula: C₄H₃F₃O
• Molecular Weight: 124.062
• Mol file: 406-88-2.mol

Synonyms:trans-4,4,4-trifluorocrotonaldehyde

Chemical Property of 4,4,4-trifluoro-but-2-enal

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4,4,4-trifluoro-but-2-enal

There total 7 articles about 4,4,4-trifluoro-but-2-enal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

(E,Z)-4,4,4-trifluoro-2-buten-1-ol (83706-94-9,83706-98-3,674-53-3) → 4,4,4-trifluorocrotonaldehyde (406-88-2)

Guidance literature:

With manganese(IV) oxide; In 1,3,5-trimethyl-benzene; at 50 ℃; for 24h; Inert atmosphere;

DOI:10.1039/c2cc32757k

Reference yield:

1,1,1-trifluoro-2-bromo-2-chloroethane (151-67-7) + ethyl vinyl ether (109-92-2,25104-37-4) → trans-4,4,4-trifluorocrotonaldehyde (406-88-2) + 3-chloro-4,4,4-trifluorobutyraldehyde

Guidance literature:

1,1,1-trifluoro-2-bromo-2-chloroethane; ethyl vinyl ether; With sodium dithionite; sodium hydrogencarbonate; In acetonitrile; at 20 - 30 ℃; for 2h;

With water;

DOI:10.1016/S0022-1139(01)00459-6

Reference yield:

ethyl 4,4,4-trifluorocrotonate (25597-16-4) → trans-4,4,4-trifluorocrotonaldehyde (406-88-2)

Guidance literature:

With diisobutylaluminium hydride; In diethyl ether; hexane; at -80 ℃; for 1h; Inert atmosphere;

DOI:10.1016/j.jfluchem.2013.07.016

upstream raw materials:

1,1,1-trifluoro-2-bromo-2-chloroethane

ethyl vinyl ether

1-trifluoromethylprop-1-en-3-ol

ethyl 4,4,4-trifluorocrotonate

Downstream raw materials:

(E)-4,4,4-trifluoro-1-phenylbut-2-en-1-ol

(E)-6,6,6-Trifluoro-1-phenyl-4-hexen-3-ol

Refernces

• 1、 Plenkiewicz, Halina,Dmowski, Wojciech,Lipínski, Miroslaw. "Sodium dithionite initiated reactions of Halothane with enol ethers: Facile synthesis of 3-trifluoromethyl substituted vinyl carbonyl compounds". . p. 227 - 232. Retrieved 2001.
• 2、 -. "The fluorine-containing α, β - production of unsaturated aldehydes". Paragraph 0067; 0068; 0071; 0072. . Retrieved 2017/09/26.
• 3、 -. "NO-RELEASING NONOATE(OXYGEN-BOUND)CHROMENE CONJUGATES". Paragraph 0224; 0225. . Retrieved 2015/08/03.