C₂₅H₄₁BN₂O₅

Base Information

• Chemical Name: C₂₅H₄₁BN₂O₅
• CAS No.: 1029701-36-7
• Molecular Formula: C₂₅H₄₁BN₂O₅
• Molecular Weight: 460.422
• Mol file: 1029701-36-7.mol

Synonyms:C₂₅H₄₁BN₂O₅

Chemical Property of C₂₅H₄₁BN₂O₅

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of C₂₅H₄₁BN₂O₅

There total 2 articles about C₂₅H₄₁BN₂O₅ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

1,3-dioxoisoindolin-2-yl (tert-butoxycarbonyl)-L-phenylalanylleucinate + [B2pin2Me]Li → C25H41BN2O5 (1029701-36-7)

Guidance literature:

With nickel(II) chloride hexahydrate; 4,4'-Dimethoxy-2,2'-bipyridin; magnesium bromide ethyl etherate; In tetrahydrofuran; N,N-dimethyl-formamide; at -15 - 20 ℃; for 2h;

DOI:10.1126/science.aam7355

Reference yield:

(R)-3-methyl-1-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)butan-1-amine hydrochloride + N-tert-butoxycarbonyl-L-phenylalanine (13734-34-4) → C25H41BN2O5 (1029701-36-7)

Guidance literature:

With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 ℃; for 7h;

DOI:10.1021/ja800829y

Reference yield:

C25H41BN2O5 (1029701-36-7) → (CH3)2CHCH2CH(BO2C2(CH3)4)NHCOCH(CH2C6H5)NH3(1+)*Cl(1-)=(CH3)2CHCH2CH(BO2C2(CH3)4)NHCOCH(CH2C6H5)NH3Cl (1029701-41-4)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; dichloromethane; at 0 - 20 ℃; for 6h;

DOI:10.1021/ja800829y

upstream raw materials:

N-tert-butoxycarbonyl-L-phenylalanine

Downstream raw materials:

(CH₃)2CHCH₂CH(BO₂C₂(CH₃)4)NHCOCH(CH₂C₆H₅)NH₃⁽¹⁺⁾*Cl^(1-)=(CH₃)2CHCH₂CH(BO₂C₂(CH₃)4)NHCOCH(CH₂C₆H₅)NH₃Cl

Refernces

• 1、 Beenen, Melissa A.,An, Chihui,Ellman, Jonathan A.. "Asymmetric copper-catalyzed synthesis of α-amino boronate esters from N-tert-butanesulfinyl aldimines". . p. 6910 - 6911. Retrieved 2008/12/22.