tert-butyl methyl(3-oxobutyl)carbamate

Base Information

• Chemical Name: tert-butyl methyl(3-oxobutyl)carbamate
• CAS No.: 1447607-14-8
• Molecular Formula: C₁₀H₁₉NO₃
• Molecular Weight: 201.266
• Mol file: 1447607-14-8.mol

Synonyms:tert-butyl methyl(3-oxobutyl)carbamate

Chemical Property of tert-butyl methyl(3-oxobutyl)carbamate

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

tert-Butylmethyl(3-oxobutyl)carbamate 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl methyl(3-oxobutyl)carbamate

There total 3 articles about tert-butyl methyl(3-oxobutyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

di-tert-butyl dicarbonate (24424-99-5) + 1-(N-benzyl-N-methyl)-amino-butan-3-one (16635-00-0) → tert-butyl methyl(3-oxobutyl)carbamate (1447607-14-8)

Guidance literature:

1-(N-benzyl-N-methyl)-amino-butan-3-one; With formic acid; palladium on activated charcoal; In methanol; for 1h; Inert atmosphere; Reflux;

di-tert-butyl dicarbonate; With sodium carbonate; In methanol; at 0 - 20 ℃; for 1h; Inert atmosphere;

DOI:10.1002/anie.201608535

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) + 4-Methylaminobutan-2-one (26387-61-1) → tert-butyl methyl(3-oxobutyl)carbamate (1447607-14-8)

Guidance literature:

With sodium carbonate; In methanol; at 0 - 20 ℃; for 1h; Inert atmosphere;

DOI:10.1002/anie.201207173

Reference yield:

1-(N-benzyl-N-methyl)-amino-butan-3-one (16635-00-0) → tert-butyl methyl(3-oxobutyl)carbamate (1447607-14-8)

Guidance literature:

Multi-step reaction with 2 steps

1: formic acid; 5%-palladium/activated carbon / methanol / 1 h / Reflux; Inert atmosphere

2: sodium carbonate / methanol / 1 h / 0 - 20 °C / Inert atmosphere

With formic acid; 5%-palladium/activated carbon; sodium carbonate; In methanol;

DOI:10.1002/anie.201207173

upstream raw materials:

1-(N-benzyl-N-methyl)-amino-butan-3-one

di-tert-butyl dicarbonate

4-Methylaminobutan-2-one

Refernces

• 1、 Zhan, Fuxu,Liang, Guangxin. "Formation of enehydrazine intermediates through coupling of phenylhydrazines with vinyl halides: Entry into the Fischer indole synthesis". . p. 1266 - 1269. Retrieved 2013/03/13.