3-Amino-6-methoxypyridine-2-carboxylic acid

Base Information

• Chemical Name: 3-Amino-6-methoxypyridine-2-carboxylic acid
• CAS No.: 870971-19-0
• Molecular Formula: C₇H₈N₂O₃
• Molecular Weight: 168.152
• Hs Code.: 29333990
• Mol file: 870971-19-0.mol

Synonyms:3-Amino-6-methoxypyridine-2-carboxylicacid

Chemical Property of 3-Amino-6-methoxypyridine-2-carboxylic acid

Chemical Property:

• Boiling Point: 384.7oC at 760 mmHg
• Flash Point: 214.7oC
• PSA: 85.44000
• Density: 1.384
• LogP: 0.95180
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

99% ^*data from raw suppliers

3-AMINO-6-METHOXYPYRIDINE-2-CARBOXYLIC ACID 95% ^*data from reagent suppliers

Safty Information:

• Statements: 20/21/22
• Safety Statements: 36/37

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Amino-6-methoxypyridine-2-carboxylic acid

There total 4 articles about 3-Amino-6-methoxypyridine-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

3-(acetylamino)-6-methoxypyridine-2-carboxylic acid (856835-28-4) → 3-amino-6-methoxypyridine-2-carboxylic acid (870971-19-0)

Guidance literature:

3-(acetylamino)-6-methoxypyridine-2-carboxylic acid; With sodium hydroxide; In water; for 1.33333h; Heating / reflux;

With hydrogenchloride; In water; at 0 ℃; pH=4;

Reference yield: 48.0%

methanol (67-56-1) + 6-bromo-2-methyl-3-nitro-pyridine (22282-96-8) → 3-amino-6-methoxypyridine-2-carboxylic acid (870971-19-0)

Guidance literature:

With selenium; cobalt(II) chloride hexahydrate; nitrobenzene; In water; dimethyl sulfoxide; at 90 ℃; for 5h; Inert atmosphere;

DOI:10.1039/d0gc04407e

Reference yield:

N-(6-methoxy-2-methyl-3-pyridyl)acetamide (52090-65-0) → 3-amino-6-methoxypyridine-2-carboxylic acid (870971-19-0)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium permanganate / water / 12 h / 100 °C

2: sodium hydroxide; water / 1 h / 100 °C

With potassium permanganate; water; sodium hydroxide; In water;

upstream raw materials:

3-(acetylamino)-6-methoxypyridine-2-carboxylic acid

N-(6-methoxy-2-methyl-3-pyridyl)acetamide

3-amino-6-methoxy-2-methylpyridine

methanol

Refernces

• 1、 -. "PAPD5 INHIBITORS AND METHODS OF USE THEREOF". Page/Page column 160-161. . Retrieved 2020/11/03.
• 2、 -. "NEW COMPOUNDS". Page/Page column 43. . Retrieved 2008/06/13.