3-BROMOTHIOPHENE-2-CARBOXAMIDE

Base Information

• Chemical Name: 3-BROMOTHIOPHENE-2-CARBOXAMIDE
• CAS No.: 76371-66-9
• Molecular Formula: C5H4BrNOS
• Molecular Weight: 206.06
• Hs Code.: 29349990
• Mol file: 76371-66-9.mol

Synonyms:5-Bromothiophene-2-carboxamide;5-Bromothiophene-2-carboxylic acid amide;3-Bromothiophene-2-carboxamide;

Chemical Property of 3-BROMOTHIOPHENE-2-CARBOXAMIDE

Chemical Property:

• Vapor Pressure: 0.0009mmHg at 25°C
• Melting Point: 77-78°C
• Refractive Index: 1.645
• Boiling Point: 318 °C at 760 mmHg
• PKA: 15.55±0.50(Predicted)
• Flash Point: 146.1 °C
• PSA: 71.33000
• Density: 1.81 g/cm³
• LogP: 2.30980
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

98%min ^*data from raw suppliers

5-Bromothiophene-2-carboxamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22-20/21/22
• Safety Statements: 3/7-24/25-36/37-15

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-BROMOTHIOPHENE-2-CARBOXAMIDE

There total 6 articles about 3-BROMOTHIOPHENE-2-CARBOXAMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

5-bromo-thiophene-2-carbaldehyde oxime (2160-63-6) → 5-bromo-2-thiophene carboxamide (76371-66-9)

Guidance literature:

With C₅₅H₄₅ClN₅P₂Ru⁽¹⁺⁾*Cl^(1-); In water; at 110 ℃; for 12h; Sealed tube;

DOI:10.1039/c6ra07515k

Reference yield: 90.0%

5-bromo-2-thiophencarboxaldehyde (4701-17-1) → 5-bromo-2-thiophene carboxamide (76371-66-9)

Guidance literature:

With tert.-butylhydroperoxide; tetraethylammonium iodide; ammonium bicarbonate; In acetonitrile; at 70 ℃; for 22h;

DOI:10.1039/c3ob42037j

Reference yield: 84.0%

5-bromothiophene-2-carboxylic acid (7311-63-9) → 5-bromo-2-thiophene carboxamide (76371-66-9)

Guidance literature:

5-bromothiophene-2-carboxylic acid; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 ℃; for 2h;

With ammonia; In water; N,N-dimethyl-formamide; at 20 ℃;

upstream raw materials:

5-bromothiophene-2-carbonyl chloride

5-bromo-2-thiophenecarbonitrile

2-Acetyl-5-bromothiophene

5-bromothiophene-2-carboxylic acid

Refernces

• 1、 Yang, Fa-Liu,Zhu, Xinju,Rao, Dun-Kang,Cao, Xiao-Niu,Li, Ke,Xu, Yan,Hao, Xin-Qi,Song, Mao-Ping. "Highly efficient synthesis of primary amides: Via aldoximes rearrangement in water under air atmosphere catalyzed by an ionic ruthenium pincer complex". . p. 37093 - 37098. Retrieved 2016/05/24.
• 2、 -. "COMPOUNDS THAT ARE ERK INHIBITORS". Page/Page column 279. . Retrieved 2009/10/18.