AZETIDINE-3-CARBONITRILE HYDROCHLORIDE

Base Information

• Chemical Name: AZETIDINE-3-CARBONITRILE HYDROCHLORIDE
• CAS No.: 345954-83-8
• Molecular Formula: C4H7ClN2
• Molecular Weight: 118.566
• Hs Code.: 29339900
• Mol file: 345954-83-8.mol

Synonyms:3-Azetidinecarbonitrile,monohydrochloride (9CI);3-Cyanoazetidine hydrochloride;

Chemical Property of AZETIDINE-3-CARBONITRILE HYDROCHLORIDE

Chemical Property:

• Vapor Pressure: 0.0624mmHg at 25°C
• Boiling Point: 227.7 °C at 760 mmHg
• Flash Point: 91.5 °C
• PSA: 35.82000
• LogP: 0.86018
• Storage Temp.: Inert atmosphere,Store in freezer, under -20°C

Purity/Quality:

98%, ^*data from raw suppliers

3-Azetidinecarbonitrile Hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): T
• Hazard Codes: T
• Statements: 25-36
• Safety Statements: 26-45

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of AZETIDINE-3-CARBONITRILE HYDROCHLORIDE

There total 3 articles about AZETIDINE-3-CARBONITRILE HYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-(1,1-diphenylmethyl)azetidine-3-carbonitrile (36476-86-5) → azetidine-3-carbonitrile hydrochloride (345954-83-8)

Guidance literature:

1-(1,1-diphenylmethyl)azetidine-3-carbonitrile; With carbonochloridic acid 1-chloro-ethyl ester; In dichloromethane; at 20 ℃; for 3h;

In methanol; at 20 ℃; for 19h; Heating / reflux;

Reference yield:

tert-butyl 3-cyanoazetidine-1-carboxylate (142253-54-1) → azetidine-3-carbonitrile hydrochloride (345954-83-8)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 2h;

Reference yield:

tert-butyl 3-cyanoazetidine-1-carboxylate (142253-54-1) → azetidine-3-carboxamide hydrochloride (124668-45-7) + azetidine-3-carbonitrile hydrochloride (345954-83-8)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; dichloromethane; at 20 ℃; for 2h; Overall yield = 99 %; Overall yield = 0.13 g;

upstream raw materials:

1-(1,1-diphenylmethyl)azetidine-3-carbonitrile

tert-butyl 3-cyanoazetidine-1-carboxylate

Refernces

• 1、 -. "As the NS4B inhibitor benzofuran analogs (by machine translation)". Paragraph 0458; 0459; 0460; 0461; 0462; 0463. . Retrieved 2016/10/31.
• 2、 -. "6,7,8,9-TETRAHYDRO-5H-1,4,7,10A-TETRAAZA-CYCLOHEPT[F]INDENE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THESE COMPOUNDS, THEIR USE AND PROCESSES FOR PREPARING THEM". Page/Page column 107-108. . Retrieved 2010/06/17.