4-Bromo-2-chlorobenzotrifluoride

Base Information

• Chemical Name: 4-Bromo-2-chlorobenzotrifluoride
• CAS No.: 467435-07-0
• Molecular Formula: C7H3 Br Cl F3
• Molecular Weight: 259.453
• Hs Code.: 2903999090
• Mol file: 467435-07-0.mol

Synonyms:4-Bromo-2-chloro-1-trifluoromethylbenzene

Chemical Property of 4-Bromo-2-chlorobenzotrifluoride

Chemical Property:

• Vapor Pressure: 0.138mmHg at 25°C
• Refractive Index: 1.5040-1.5080
• Boiling Point: 224.1°Cat760mmHg
• Flash Point: 89.3°C
• PSA: 0.00000
• Density: 1.717g/cm³
• LogP: 4.12130
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

4-Bromo-2-chlorobenzotrifluoride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Bromo-2-chlorobenzotrifluoride

There total 1 articles about 4-Bromo-2-chlorobenzotrifluoride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

3-chloro-4-(trifluoromethyl)aniline (445-13-6) → 4-bromo-2-chloro-1-(trifluoromethyl)benzene (467435-07-0)

Guidance literature:

With tert.-butylnitrite; copper(ll) bromide; In acetonitrile; at 45 ℃; for 3h;

Reference yield: 99.0%

carbon dioxide (124-38-9,18923-20-1) + 4-bromo-2-chloro-1-(trifluoromethyl)benzene (467435-07-0) → 6-bromo-2-chloro-3-(trifluoromethyl)benzoic acid

Guidance literature:

4-bromo-2-chloro-1-(trifluoromethyl)benzene; With lithium diisopropyl amide; In tetrahydrofuran; n-heptane; ethylbenzene; at -78 ℃; for 1.16667h; Inert atmosphere;

carbon dioxide; In tetrahydrofuran; n-heptane; ethylbenzene; at -78 ℃; for 1h; Cooling with ice;

Reference yield: 94.3%

ethyl acrylate (140-88-5,9003-32-1) + 4-bromo-2-chloro-1-(trifluoromethyl)benzene (467435-07-0) → ethyl 3-(3-chloro-4-(trifluoromethyl)phenyl)acrylate (155626-44-1)

Guidance literature:

With 1,4-diaza-bicyclo[2.2.2]octane; potassium carbonate; palladium diacetate; In N,N-dimethyl-formamide; at 110 ℃; for 1h;

upstream raw materials:

3-chloro-4-(trifluoromethyl)aniline

Downstream raw materials:

(3-chloro-4-trifluoromethyl-phenyl)-oxo-acetic acid

ethyl 3-(3-chloro-4-(trifluoromethyl)phenyl)acrylate

3-(3-chloro-4-(trifluoromethyl)phenyl)propanoic acid

ethyl 3-(3-chloro-4-(trifluoromethyl)phenyl)propanoate

Refernces