4-HYDROXYPHENYLGLYOXAL HYDRATE

Base Information

• Chemical Name: 4-HYDROXYPHENYLGLYOXAL HYDRATE
• CAS No.: 197447-05-5
• Molecular Formula: C₈H₈O₄
• Molecular Weight: 168.149
• Hs Code.: 2918990090
• Mol file: 197447-05-5.mol

Synonyms:benzeneacetaldehyde, 4-hydroxy-α-oxo-, hydrate (1:1);(4-Hydroxyphenyl)(oxo)acetaldehyde hydrate (1:1);

Chemical Property of 4-HYDROXYPHENYLGLYOXAL HYDRATE

Chemical Property:

• Vapor Pressure: 8.97E-07mmHg at 25°C
• Melting Point: 108-110 °C
• Boiling Point: 389.8 °C at 760 mmHg
• Flash Point: 189.5 °C
• PSA: 63.60000
• LogP: 0.70950
• Solubility.: DMSO (Slightly), Methanol (Slightly)

Purity/Quality:

98%min ^*data from raw suppliers

4-Hydroxyphenylglyoxalhydrate ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 4-Hydroxyphenylglyoxal Hydrate is a useful building block in the synthesis of various pharmaceuticals.

Technology Process of 4-HYDROXYPHENYLGLYOXAL HYDRATE

There total 2 articles about 4-HYDROXYPHENYLGLYOXAL HYDRATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-Hydroxyacetophenone (99-93-4) → 2,2-dihydroxy-1-(4-hydroxyphenyl)ethan-1-one (197447-05-5)

Guidance literature:

With iodine; In dimethyl sulfoxide; at 100 ℃;

DOI:10.1016/j.tet.2012.10.072

Reference yield:

(4-hydroxylphenyl)glyoxal (24645-80-5) → 2,2-dihydroxy-1-(4-hydroxyphenyl)ethan-1-one (197447-05-5)

Guidance literature:

With water; for 5h; Reflux; Inert atmosphere;

DOI:10.1055/s-0031-1289613

Reference yield: 85.0%

4-hydroxy[1]benzopyran-2-one (1076-38-6,92395-12-5) + 2,2-dihydroxy-1-(4-hydroxyphenyl)ethan-1-one (197447-05-5) → 3-(4-hydroxy-2-oxo-2H-chromen-3-yl)-2-(4-hydroxyphenyl)-4H-furo[3,2-c]chromen-4-one

Guidance literature:

With methanesulfonic acid; In toluene; for 1h; Reflux; Green chemistry;

DOI:10.1039/c8ob00942b

upstream raw materials:

(4-hydroxylphenyl)glyoxal

4-Hydroxyacetophenone

Downstream raw materials:

N-[2-(4-hydroxyphenyl)imidazo[1,2-a]pyridin-3-yl]-4-methylbenzenesulfonamide

Refernces

• 1、 Khalafy, Jabbar,Ilkhanizadeh, Siamand,Ranjbar, Masoumeh. "A Green, Organometallic Catalyzed Synthesis of a Series of Novel Functionalized 4-Aroyl-4H-benzo[g]chromenes through One-pot, Three Component Reaction". . p. 951 - 956. Retrieved 2018/02/15.
• 2、 Javahershenas, Ramin,Khalafy, Jabbar. "A Green Synthesis of 7-amino-5-(4-aroyl)-1,3-dimethyl-2,4-dioxo-1,2,3,4,5,8-hexahydropyrido[2,3-d]pyrimidine-6-carbonitrile Derivatives by a One-pot Three-component Reaction". . p. 3163 - 3168. Retrieved 2017/10/06.