1-NAPHTHYLGLYOXAL HYDRATE

Base Information

• Chemical Name: 1-NAPHTHYLGLYOXAL HYDRATE
• CAS No.: 16208-20-1
• Molecular Formula: C12H10O3
• Molecular Weight: 202.21
• Hs Code.: 2922509090
• Mol file: 16208-20-1.mol

Synonyms:1'-Acetonaphthone,2,2-dihydroxy- (8CI);

Chemical Property of 1-NAPHTHYLGLYOXAL HYDRATE

Chemical Property:

• Vapor Pressure: 3.58E-07mmHg at 25°C
• Boiling Point: 401.7 °C at 760 mmHg
• Flash Point: 196.7 °C
• PSA: 57.53000
• LogP: 1.33320

Purity/Quality:

98%min ^*data from raw suppliers

Naphth-1-ylglyoxal hydrate 95.0% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-NAPHTHYLGLYOXAL HYDRATE

There total 2 articles about 1-NAPHTHYLGLYOXAL HYDRATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1'-naphthacetophenone (941-98-0) → 2-(naphthalen-1-yl)-2-oxoacetaldehyde hydrate (16208-20-1)

Guidance literature:

With iodine; In dimethyl sulfoxide; at 100 ℃;

DOI:10.1016/j.tet.2012.10.072

Reference yield:

1-naphthylglyoxal (63464-85-7) → 2-(naphthalen-1-yl)-2-oxoacetaldehyde hydrate (16208-20-1)

Guidance literature:

With water; for 0.0833333h; Reflux;

DOI:10.1021/acs.joc.6b01040

Reference yield: 100.0%

diazoacetic acid ethyl ester (623-73-4) + 2-(naphthalen-1-yl)-2-oxoacetaldehyde hydrate (16208-20-1) + 4-methoxy-aniline (104-94-9) → ethyl (2R,3S)-3-(1-naphthoyl)-1-(4-methoxyphenyl)aziridine-2-carboxylate (1153714-91-0)

Guidance literature:

2-(naphthalen-1-yl)-2-oxoacetaldehyde hydrate; 4-methoxy-aniline; With (R)-3,3'-bis(tris(4-tert-butylphenyl)silyl)-1,1'-binaphthyl-2,2'-diyl hydrogenphosphate; In toluene; at 20 ℃; for 1h;

diazoacetic acid ethyl ester; In toluene; at -30 ℃; for 23h; optical yield given as %ee; enantioselective reaction;

DOI:10.1021/ol900674t

upstream raw materials:

1'-naphthacetophenone

1-naphthylglyoxal

Downstream raw materials:

ethyl (2R,3S)-3-(1-naphthoyl)-1-(4-methoxyphenyl)aziridine-2-carboxylate

5-bromo-N-(1-(4-chlorophenylamino)-2-(naphthalen-1-yl)-2-oxoethyl)picolinamide

3-(1-naphthyl)-7-benzoyl-quinoxaline

5-(naphthalen-1-yl)-2-phenyloxazole

Refernces

• 1、 Wu, Wangbin,Zou, Sijia,Lin, Lili,Ji, Jie,Zhang, Yuheng,Ma, Baiwei,Liu, Xiaohua,Feng, Xiaoming. "Catalytic asymmetric Meerwein-Ponndorf-Verley reduction of glyoxylates induced by a chiral N,N′-dioxide/Y(OTf)3 complex". supporting information. p. 3232 - 3235. Retrieved 2017/03/20.
• 2、 Khodabakhshi, Saeed,Karami, Bahador,Eskandari, Khalil. "Molybdate sulfuric acid-catalyzed one-pot synthesis of substituted coumarins under solvent-free conditions". . p. 7263 - 7272. Retrieved 2015/09/29.