Pyrazolo[1,5-a]pyridine-2,3-dicarboxylic acid

Base Information

• Chemical Name: Pyrazolo[1,5-a]pyridine-2,3-dicarboxylic acid
• CAS No.: 63237-87-6
• Molecular Formula: C9H6N2O4
• Molecular Weight: 206.158
• Hs Code.: 2933990090
• DSSTox Substance ID: DTXSID60427815
• Mol file: 63237-87-6.mol

Synonyms:Pyrazolo[1,5-a]pyridine-2,3-dicarboxylic acid;63237-87-6;Pyrazolo[1,5-a]pyridine-2,3-dicarboxylicacid;MFCD06797491;SCHEMBL2809874;DTXSID60427815;AKOS015950492;AB29659;AC-3275;SY004703;pyrazolo[1,5-a]pyridine-2,3-dicarboxylic;CS-0085167;A51102;A834289;F2199-0083

Chemical Property of Pyrazolo[1,5-a]pyridine-2,3-dicarboxylic acid

Chemical Property:

• Melting Point: 218-218.5 °C
• Refractive Index: 1.718
• PSA: 91.90000
• Density: 1.64 g/cm³
• LogP: 0.73070
• Storage Temp.: Sealed in dry,Store in freezer, under -20°C
• XLogP3: 0.4
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 2
• Exact Mass: 206.03275668
• Heavy Atom Count: 15
• Complexity: 294

Purity/Quality:

99% ^*data from raw suppliers

Pyrazolo[1,5-a]pyridine-2,3-dicarboxylicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC2=C(C(=NN2C=C1)C(=O)O)C(=O)O

Technology Process of Pyrazolo[1,5-a]pyridine-2,3-dicarboxylic acid

There total 4 articles about Pyrazolo[1,5-a]pyridine-2,3-dicarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

pyrazolo<1,5-a>pyridine-2,3-dicarboxylic acid dimethyl ester (5825-71-8) → pyrazolo[1,5-a]pyridine-2,3-dicarboxylic acid (63237-87-6)

Guidance literature:

With sodium hydroxide; In methanol; water; for 1h; Reflux;

DOI:10.3390/molecules23112740

Reference yield:

pyridine (110-86-1) → pyrazolo[1,5-a]pyridine-2,3-dicarboxylic acid (63237-87-6)

Guidance literature:

Multi-step reaction with 3 steps

1: O-(diphenylphosphinyl)hydroxylamine / water / 16 h / 80 °C

2: potassium carbonate / N,N-dimethyl-formamide / 16 h / 20 °C

3: water; lithium hydroxide / tetrahydrofuran / 16 h / 20 °C

With O-(diphenylphosphinyl)hydroxylamine; water; potassium carbonate; lithium hydroxide; In tetrahydrofuran; water; N,N-dimethyl-formamide;

Reference yield:

N-iminopyridinium ylide (25275-41-6) → pyrazolo[1,5-a]pyridine-2,3-dicarboxylic acid (63237-87-6)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / N,N-dimethyl-formamide / 16 h / 20 °C

2: water; lithium hydroxide / tetrahydrofuran / 16 h / 20 °C

With water; potassium carbonate; lithium hydroxide; In tetrahydrofuran; N,N-dimethyl-formamide;

upstream raw materials:

pyrazolo<1,5-a>pyridine-2,3-dicarboxylic acid dimethyl ester

pyridine

N-iminopyridinium ylide

Downstream raw materials:

Pyrazolo[1,5-a]pyridine-2,3-dicarboxylic acid bis-phenylamide

Refernces

• 1、 -. "SPIRO-OXADIAZOLINE COMPOUNDS AS AGONISTS OF α-7-NICOTINIC ACETYLCHOLINE RECEPTORS". Paragraph 00280-00281. . Retrieved 2015/05/19.