5-Chloro-2-hydrazinylpyridine

Base Information

• Chemical Name: 5-Chloro-2-hydrazinylpyridine
• CAS No.: 27032-63-9
• Molecular Formula: C5H6ClN3
• Molecular Weight: 143.576
• Hs Code.: 2933990090
• European Community (EC) Number: 836-443-9
• DSSTox Substance ID: DTXSID00544535
• Nikkaji Number: J2.135.634D
• Wikidata: Q82421659
• Mol file: 27032-63-9.mol

Synonyms:27032-63-9;5-chloro-2-hydrazinylpyridine;5-Chloro-2-hydrazinopyridine;(5-CHLORO-PYRIDIN-2-YL)-HYDRAZINE;(5-Chloropyridin-2-yl)hydrazine;MFCD07786313;Pyridine,5-chloro-2-hydrazinyl-;1-(5-chloropyridin-2-yl)hydrazine;2(1H)-Pyridinone, 5-chloro-, hydrazone;2-hydrazino-5-chloropyridine;3-chloro-6-hydrazinopyridine;SCHEMBL1432907;DTXSID00544535;UXJYFOOFLZGBEK-UHFFFAOYSA-N;BCP15596;AKOS000112929;AM84861;CS-W005325;GA-0724;SB75435;SY045855;EN300-111786;A877040;J-517307;5-Chloro-2-hydrazinylpyridine

Chemical Property of 5-Chloro-2-hydrazinylpyridine

Chemical Property:

• Vapor Pressure: 288oC at 760mmHg
• Melting Point: 127-128
• Boiling Point: 288.012 °C at 760 mmHg
• PKA: 9.00±0.70(Predicted)
• Flash Point: 127.985 °C
• PSA: 50.94000
• Density: 1.418 g/cm³
• LogP: 1.79390
• Storage Temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
• XLogP3: 1
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 143.0250249
• Heavy Atom Count: 9
• Complexity: 88.3

Purity/Quality:

98%,99%, ^*data from raw suppliers

5-Chloro-2-hydrazinopyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=NC=C1Cl)NN

Technology Process of 5-Chloro-2-hydrazinylpyridine

There total 7 articles about 5-Chloro-2-hydrazinylpyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

2,5 dichloropyridine (16110-09-1) → 5-chloro-pyridin-2-yl hydrazine (27032-63-9)

Guidance literature:

With pyridine; hydrazine hydrate; for 6h; Reflux;

DOI:10.1021/ja2005175

Reference yield: 82.0%

2-Bromo-5-chloro-pyridine (40473-01-6) → 5-chloro-pyridin-2-yl hydrazine (27032-63-9)

Guidance literature:

With hydrazine hydrate; In isopropyl alcohol; for 10h; Reflux;

DOI:10.1007/s10593-017-2040-x

Reference yield:

5-chloro-2-pyridylamine (1072-98-6) → 5-chloro-pyridin-2-yl hydrazine (27032-63-9)

Guidance literature:

Multi-step reaction with 2 steps

1: bromine; hydrogen bromide; sodium nitrite / water / 1.5 h / 0 - 10 °C

2: hydrazine hydrate / isopropyl alcohol / 10 h / Reflux

With hydrogen bromide; bromine; hydrazine hydrate; sodium nitrite; In water; isopropyl alcohol;

DOI:10.1007/s10593-017-2040-x

upstream raw materials:

2,5 dichloropyridine

5-chloro-2-pyridylamine

2-Bromo-5-chloro-pyridine

Downstream raw materials:

cyclohexanone (5-chloropyridin-2-yl)hydrazone

5-chloro-2-pyridylamine

3-chloro-6-methyl-6,7,8,9-tetrahydro-5H-pyrido-[3',4':4,5]pyrrolo[2,3-b]pyridine

C₇H₄ClN₃O₂

Refernces

• 1、 -. "HUMAN PLASMA KALLIKREIN INHIBITORS". Page/Page column 147. . Retrieved 2015/11/02.
• 2、 Hapuarachchige, Sudath,Montano, Gilbert,Ramesh, Chinnasamy,Rodriguez, Delany,Henson, Lauren H.,Williams, Casey C.,Kadavakkollu, Samuel,Johnson, Dennis L.,Shuster, Charles B.,Arterburn, Jeffrey B.. "Design and synthesis of a new class of membrane-permeable triazaborolopyridinium fluorescent probes". supporting information; experimental part. p. 6780 - 6790. Retrieved 2011/06/22.