4-Pyrimidin-2-ylbenzoyl chloride

Base Information

• Chemical Name: 4-Pyrimidin-2-ylbenzoyl chloride
• CAS No.: 679806-84-9
• Molecular Formula: C11H7ClN2O
• Molecular Weight: 218.642
• Hs Code.: 2933599090
• Mol file: 679806-84-9.mol

Synonyms:4-Pyrimidin-2-ylbenzoylchloride;

Chemical Property of 4-Pyrimidin-2-ylbenzoyl chloride

Chemical Property:

• Vapor Pressure: 0.0065mmHg at 25°C
• Melting Point: 172.5 °C
• Refractive Index: 1.599
• Boiling Point: 271.3 °C at 760 mmHg
• Flash Point: 117.9 °C
• PSA: 42.85000
• Density: 1.304 g/cm³
• LogP: 2.52260

Purity/Quality:

98% ^*data from raw suppliers

4-Pyrimidin-2-ylbenzoyl chloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): C
• Hazard Codes: C

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Pyrimidin-2-ylbenzoyl chloride

There total 1 articles about 4-Pyrimidin-2-ylbenzoyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

4-(pyrimidine-2-yl)benzoic acid (199678-12-1) → 4-pyrimidin-2-yl-benzoyl chloride (679806-84-9)

Guidance literature:

With oxalyl dichloride; N,N-dimethyl-formamide; In tetrahydrofuran; at 20 ℃; for 3h;

Reference yield:

8-amino quinoline (578-66-5) + 4-pyrimidin-2-yl-benzoyl chloride (679806-84-9) → C20H14N4O

Guidance literature:

8-amino quinoline; With triethylamine; In dichloromethane;

4-pyrimidin-2-yl-benzoyl chloride; In dichloromethane; at 0 - 20 ℃;

DOI:10.1055/s-0036-1589011

Reference yield:

N-(pyridin-3-ylmethyl)-10,11-dihydro-5H-pyrrolo[2,1-c][1,4]benzodiazepine-3-carboxamide (917373-65-0) + 4-pyrimidin-2-yl-benzoyl chloride (679806-84-9) → N-(Pyridin-3-ylmethyl)-10-(4-pyrimidin-2-ylbenzoyl)-10,11-dihydro-5H-pyrrolo[2,1-c][1,4]benzodiazepine-3-carboxamide (917374-83-5)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 20 ℃; for 20h;

upstream raw materials:

4-(pyrimidine-2-yl)benzoic acid

Downstream raw materials:

N-(Pyridin-3-ylmethyl)-10-(4-pyrimidin-2-ylbenzoyl)-10,11-dihydro-5H-pyrrolo[2,1-c][1,4]benzodiazepine-3-carboxamide

Refernces

• 1、 -. "Pyrrolobenzodiazepine pyridine carboxamides and derivatives as follicle-stimulating hormone receptor antagonists". Page/Page column 51. . Retrieved 2010/11/25.