1-(5-Bromopyridin-3-yl)-N-methylmethanamine

Base Information

• Chemical Name: 1-(5-Bromopyridin-3-yl)-N-methylmethanamine
• CAS No.: 73335-64-5
• Molecular Formula: C₇H₉BrN₂
• Molecular Weight: 201.066
• Hs Code.: 2933399090
• European Community (EC) Number: 800-962-9
• DSSTox Substance ID: DTXSID40501021
• Wikidata: Q82353099
• Mol file: 73335-64-5.mol

Synonyms:73335-64-5;1-(5-Bromopyridin-3-yl)-N-methylmethanamine;N-METHYL-(5-BROMOPYRID-3-YL)METHYLAMINE;[(5-bromopyridin-3-yl)methyl](methyl)amine;3-Pyridinemethanamine, 5-bromo-N-methyl-;N-METHYL-(5-BROMOPYRIDIN-3-YL)METHYLAMINE;SCHEMBL1750523;DTXSID40501021;UHDHQYPCHVXIKK-UHFFFAOYSA-N;MFCD07375057;(5-bromopyrid-3-ylmethyl)methylamine;AKOS009344107;(5-bromopyridin-3-ylmethyl)methylamine;AB41067;FS-3210;FT-0694276;C76339;EN300-315099;A837794;1-(5-BROMO-3-PYRIDYL)-N-METHYL-METHANAMINE;J-503420

Chemical Property of 1-(5-Bromopyridin-3-yl)-N-methylmethanamine

Chemical Property:

• Vapor Pressure: 0.0199mmHg at 25°C
• Refractive Index: 1.556
• Boiling Point: 251.9 °C at 760 mmHg
• Flash Point: 106.2 °C
• PSA: 24.92000
• Density: 1.431 g/cm³
• LogP: 1.95440
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• XLogP3: 0.9
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 199.99491
• Heavy Atom Count: 10
• Complexity: 97.6

Purity/Quality:

98%min ^*data from raw suppliers

1-(5-Bromopyridin-3-yl)-N-methylmethanamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): C
• Hazard Codes: C

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CNCC1=CC(=CN=C1)Br

Technology Process of 1-(5-Bromopyridin-3-yl)-N-methylmethanamine

There total 2 articles about 1-(5-Bromopyridin-3-yl)-N-methylmethanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.5%

5-bromopyridine-3-carbaldehyde (113118-81-3) + methylamine hydrochloride (593-51-1) → 1-(5-bromopyridin-3-yl)-N-methylmethanamine (73335-64-5)

Guidance literature:

With sodium cyanoborohydride; triethylamine; In methanol; at 0 - 20 ℃; for 1.5h;

Reference yield:

→ 1-(5-bromopyridin-3-yl)-N-methylmethanamine (73335-64-5)

Guidance literature:

With acetic acid; In tetrahydrofuran; methanol; at 15 - 25 ℃; for 12h;

With sodium tris(acetoxy)borohydride; In tetrahydrofuran; methanol; at 15 - 25 ℃; for 2h;

Reference yield: 51.3%

1-(5-bromopyridin-3-yl)-N-methylmethanamine (73335-64-5) + di-tert-butyl dicarbonate (24424-99-5) → tert-butyl-((5-bromopyridin-3-yl)methyl)(methyl)carbamate

Guidance literature:

With dmap; triethylamine; In dichloromethane; at 20 ℃;

upstream raw materials:

5-bromopyridine-3-carbaldehyde

methylamine hydrochloride

Downstream raw materials:

tert-butyl {2-[methyl({5-[4-(morpholin-4-yl)phenyl]pyridin-3-yl}methyl)amino]-2-oxoethyl}carbamate

Refernces

• 1、 -. "1H-INDAZOLE-3-CARBOXAMIDE COMPOUNDS AS GLYCOGEN SYNTHASE KINASE 3 BETA INHIBITORS". Page/Page column 34-36. . Retrieved 2020/01/10.
• 2、 -. "NOVEL COMPOUNDS THAT MODULATE PPARγ TYPE RECEPTORS, AND USE THEREOF IN COSMETIC OR PHARMACEUTICAL COMPOSITIONS". Page 44-45. . Retrieved 2008/06/13.