Ethyl 2-chloro-1,3-oxazole-5-carboxylate

Base Information

• Chemical Name: Ethyl 2-chloro-1,3-oxazole-5-carboxylate
• CAS No.: 862599-47-1
• Molecular Formula: C6H6ClNO3
• Molecular Weight: 175.572
• Hs Code.: 2934999090
• Mol file: 862599-47-1.mol

Synonyms:Ethyl2-chloro-oxazole-5-carboxylate;

Chemical Property of Ethyl 2-chloro-1,3-oxazole-5-carboxylate

Chemical Property:

• Vapor Pressure: 0.0176mmHg at 25°C
• Refractive Index: 1.487
• Boiling Point: 254.1 °C at 760 mmHg
• PKA: -2?+-.0.10(Predicted)
• Flash Point: 107.5 °C
• PSA: 52.33000
• Density: 1.332 g/cm³
• LogP: 1.50470
• Storage Temp.: Keep Cold

Purity/Quality:

98%,99%, ^*data from raw suppliers

Ethyl2-Chlorooxazole-5-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Ethyl 2-chloro-1,3-oxazole-5-carboxylate

There total 2 articles about Ethyl 2-chloro-1,3-oxazole-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

oxazol-5-yl-carboxylic acid ethyl ester (118994-89-1) → ethyl 2-chloro-1,3-oxazole-5-carboxylate (862599-47-1)

Guidance literature:

oxazol-5-yl-carboxylic acid ethyl ester; With lithium hexamethyldisilazane; In tetrahydrofuran; at -42 ℃; for 0.5h;

With hexachloroethane; In tetrahydrofuran; at 20 ℃; for 42h;

DOI:10.1021/ol051244x

Reference yield: 40.0%

2-amino-oxazole-5-carboxylic acid ethyl ester (113853-16-0) → ethyl 2-chloro-1,3-oxazole-5-carboxylate (862599-47-1)

Guidance literature:

With tert.-butylnitrite; copper dichloride; at 60 - 80 ℃; for 2h; Inert atmosphere;

DOI:10.1016/j.ejmech.2016.11.003

Reference yield: 97.0%

ethyl 2-chloro-1,3-oxazole-5-carboxylate (862599-47-1) + 6-chloro-1-(phenylsulfonyl)-4-(trimethylstannanyl)-1H-indazole (1254036-80-0) → ethyl 2-[6-chloro-1-(phenylsulfonyl)-1H-indazol-4-yl]-1,3-oxazole-5-carboxylate (1254036-81-1)

Guidance literature:

With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In N,N-dimethyl-formamide; at 100 ℃; for 2h; Inert atmosphere;

DOI:10.1021/acs.jmedchem.5b00767

upstream raw materials:

oxazol-5-yl-carboxylic acid ethyl ester

2-amino-oxazole-5-carboxylic acid ethyl ester

Downstream raw materials:

2-((2R,4S)-4-{(3,5-bis-trifluoromethyl-benzyl)-[5-(1-methyl-1H-pyrazol-4-yl)-pyrimidin-2-yl]-amino}-2-ethyl-pyrrolidin-1-yl)-oxazole-4-carboxylic acid ethyl ester

ethyl 2-[6-chloro-1-(phenylsulfonyl)-1H-indazol-4-yl]-1,3-oxazole-5-carboxylate

ethyl 2-vinyloxazole-5-carboxylate

2-oxo-2,3-dihydrooxazole-5-carboxylic acid

Refernces

• 1、 -. "HETEROARLY AMIDES AS INHIBITORS OF PROTEIN AGGREGATION". Paragraph 0116. . Retrieved 2015/09/23.