N, N'-di-(tert-butoxycarbonyl)-3,4-diaminotoluene

Base Information

• Chemical Name: N, N'-di-(tert-butoxycarbonyl)-3,4-diaminotoluene
• CAS No.: 1282523-80-1
• Molecular Formula: C₁₇H₂₆N₂O₄
• Molecular Weight: 322.404
• Mol file: 1282523-80-1.mol

Synonyms:N, N'-di-(tert-butoxycarbonyl)-3,4-diaminotoluene

Chemical Property of N, N'-di-(tert-butoxycarbonyl)-3,4-diaminotoluene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N, N'-di-(tert-butoxycarbonyl)-3,4-diaminotoluene

There total 1 articles about N, N'-di-(tert-butoxycarbonyl)-3,4-diaminotoluene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

di-tert-butyl dicarbonate (24424-99-5) + 4-methyl-1,2-diaminobenzene (496-72-0) → N, N'-di-(tert-butoxycarbonyl)-3,4-diaminotoluene (1282523-80-1)

Guidance literature:

With iron oxide; In ethanol; at 20 ℃; for 0.75h; chemoselective reaction; Green chemistry;

DOI:10.1016/j.crci.2013.05.010

Reference yield:

N, N'-di-(tert-butoxycarbonyl)-3,4-diaminotoluene (1282523-80-1) + ethanolamine (141-43-5) → C20H31N3O6

Guidance literature:

With triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In N,N-dimethyl-formamide; at 20 ℃; for 12h;

DOI:10.1016/j.jinorgbio.2021.111508

upstream raw materials:

di-tert-butyl dicarbonate

4-methyl-1,2-diaminobenzene

Refernces

• 1、 Zolfigol, Mohammad Ali,Moosavi-Zare, Ahmad Reza,Moosavi, Parvin,Khakyzadeh, Vahid,Zare, Abdolkarim. "Nano-ferrous ferric oxide (nano-Fe3O4): Powerful, reusable, and stable catalyst for N-Boc protection of amines". . p. 962 - 966. Retrieved 2013/11/06.
• 2、 Chehardoli, Gholamabbas,Zolfigol, Mohammad Ali,Khakyzadeh, Vahid,Golbedaghi, Reza,Hall, Nikita A.,Blackman, Allan G.. "Synthesis and crystal structure determination of [H2-cryptand 222](Br3)2: A unique tribromide catalyst for the catalytic chemoselective N-boc protection of amines". experimental part. p. 538 - 543. Retrieved 2012/01/03.