4-cyanophenyl pivalate

Base Information

• Chemical Name: 4-cyanophenyl pivalate
• CAS No.: 180143-65-1
• Molecular Formula: C₁₂H₁₃NO₂
• Molecular Weight: 203.241
• Mol file: 180143-65-1.mol

Synonyms:4-cyanophenyl pivalate

Chemical Property of 4-cyanophenyl pivalate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of 4-cyanophenyl pivalate

There total 2 articles about 4-cyanophenyl pivalate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

pivaloyl chloride (3282-30-2) + 4-cyanophenol (767-00-0) → 4-cyanophenyl pivalate (180143-65-1)

Guidance literature:

With pyridine; In dichloromethane; at 20 ℃; for 16h; Inert atmosphere; Schlenk technique;

DOI:10.1039/d0cc01803a

Reference yield: 56.0%

potassium (4-cyanophenyl)trifluoroborate (850623-36-8) + sodium pivalate (1184-88-9) → 4-cyanophenyl pivalate (180143-65-1)

Guidance literature:

With copper(II) bis(trifluoromethanesulfonate); In acetonitrile; at 25 ℃; for 16h; Sealed tube;

DOI:10.1055/s-0035-1562529

Reference yield: 100.0%

2-amino-benzenethiol (137-07-5) + 4-cyanophenyl pivalate (180143-65-1) → 2-(tert-butyl)benzo[d]thiazole (17626-88-9) + 4-cyanophenol (767-00-0)

Guidance literature:

With 1-methyl-pyrrolidin-2-one; potassium carbonate; at 100 ℃; for 1.5h;

DOI:10.1021/jo990780y

upstream raw materials:

pivaloyl chloride

4-cyanophenol

potassium (4-cyanophenyl)trifluoroborate

sodium pivalate

Downstream raw materials:

N-pivaloyl-p-chlorophenylmethylamine

N-(4-methoxybenzyl)pivalamide

N-benzyl-2,2-dimethylpropanamide

2-(tert-butyl)benzo[d]thiazole

Refernces

• 1、 Xi, Xiaoxiang,Chen, Tieqiao,Zhang, Ji-Shu,Han, Li-Biao. "Efficient and selective hydrogenation of C-O bonds with a simple sodium formate catalyzed by nickel". supporting information. p. 1521 - 1524. Retrieved 2018/02/19.
• 2、 Yang, Jia,Xiao, Jing,Chen, Tieqiao,Han, Li-Biao. "Nickel-Catalyzed Phosphorylation of Phenol Derivatives via C-O/P-H Cross-Coupling". . p. 3911 - 3916. Retrieved 2016/05/24.