4-HYDROXY-7-METHOXYINDAN

Base Information

• Chemical Name: 4-HYDROXY-7-METHOXYINDAN
• CAS No.: 38998-04-8
• Molecular Formula: C₁₀H₁₂O₂
• Molecular Weight: 164.204
• Hs Code.: 2909499000
• Mol file: 38998-04-8.mol

Synonyms:4-Indanol,7-methoxy- (6CI);4-Methoxy-7-indanol;7-Methoxy-4-indanol;

Chemical Property of 4-HYDROXY-7-METHOXYINDAN

Chemical Property:

• Vapor Pressure: 0.000174mmHg at 25°C
• Refractive Index: 1.581
• Boiling Point: 320.1 °C at 760 mmHg
• PKA: 10.88±0.20(Predicted)
• Flash Point: 197.1 °C
• PSA: 29.46000
• Density: 1.164 g/cm³
• LogP: 1.88950

Purity/Quality:

99% ^*data from raw suppliers

4-Hydroxy-7-methoxyindane ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-HYDROXY-7-METHOXYINDAN

There total 10 articles about 4-HYDROXY-7-METHOXYINDAN which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.4%

4,7-dimethoxyindane (38998-05-9) → 7-methoxy-indan-4-ol (38998-04-8)

Guidance literature:

4,7-dimethoxyindane; With boron tribromide; In dichloromethane; at 0 - 10 ℃; for 2h;

With water; In dichloromethane;

Reference yield:

INDANE (496-11-7) → 7-methoxy-indan-4-ol (38998-04-8)

Guidance literature:

Multi-step reaction with 6 steps

1: AlCl₃

2: AlCl₃

3: AlCl₃ / toluene / Ambient temperature

4: HCO₂H, aq. H₂O₂

5: aq. KH₂PO₄, Na₂S₂O₄

6: aq. NaOH

With sodium hydroxide; potassium dihydrogenphosphate; aluminium trichloride; formic acid; sodium dithionite; dihydrogen peroxide; In toluene;

Reference yield:

4-Acetyl-6-tert-butylindan (38997-96-5) → 7-methoxy-indan-4-ol (38998-04-8)

Guidance literature:

Multi-step reaction with 4 steps

1: AlCl₃ / toluene / Ambient temperature

2: HCO₂H, aq. H₂O₂

3: aq. KH₂PO₄, Na₂S₂O₄

4: aq. NaOH

With sodium hydroxide; potassium dihydrogenphosphate; aluminium trichloride; formic acid; sodium dithionite; dihydrogen peroxide; In toluene;

upstream raw materials:

1-(7-methoxyindan-4-yl)ethanone

Indan-4,7-diol

dimethyl sulfate

INDANE

Downstream raw materials:

3-[4-(7-methoxy-indan-4-yloxy)-3,5-dimethyl-pyrazol-1-yl]-propionic acid ethyl ester

Refernces

• 1、 -. "NOVEL COMPOUNDS". Page/Page column 36. . Retrieved 2009/01/24.