2-Hydroxy-6-methylquinoxaline

Base Information

• Chemical Name: 2-Hydroxy-6-methylquinoxaline
• CAS No.: 5762-64-1
• Molecular Formula: C9H8N2O
• Molecular Weight: 160.175
• Hs Code.: 2933990090
• DSSTox Substance ID: DTXSID90460795
• Nikkaji Number: J2.937.135K
• Wikidata: Q82284946
• Mol file: 5762-64-1.mol

Synonyms:2-Hydroxy-6-methylquinoxaline;5762-64-1;6-methylquinoxalin-2-ol;6-methyl-1H-quinoxalin-2-one;6-methyl-2(1h)-quinoxalinone;SCHEMBL2619271;SCHEMBL14239549;DTXSID90460795;FT-0612570;A831532

Chemical Property of 2-Hydroxy-6-methylquinoxaline

Chemical Property:

• Melting Point: 274 °C
• Refractive Index: 1.644
• PKA: 9.21±0.70(Predicted)
• PSA: 46.01000
• Density: 1.26 g/cm³
• LogP: 1.64380
• XLogP3: 1.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 160.063662883
• Heavy Atom Count: 12
• Complexity: 225

Purity/Quality:

98%Min ^*data from raw suppliers

2-HYDROXY-6-METHYLQUINOXALINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC2=C(C=C1)NC(=O)C=N2

Technology Process of 2-Hydroxy-6-methylquinoxaline

There total 3 articles about 2-Hydroxy-6-methylquinoxaline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-methyl-1,2-diaminobenzene (496-72-0) + butyl glyoxalate (6295-06-3) → 7-methylquinoxalin-2(1H)-one (5762-65-2) + 6-methylquinoxaline-2(1H)-one (5762-64-1)

Guidance literature:

With ethanol;

DOI:10.1021/ja01169a001

Reference yield:

bromoacetic acid (79-08-3) + 4-methyl-1,2-diaminobenzene (496-72-0) → 7-methylquinoxalin-2(1H)-one (5762-65-2) + 6-methylquinoxaline-2(1H)-one (5762-64-1)

Guidance literature:

With zinc; Behandeln des Reaktionsprodukts in H₂O mit wss. H₂O₂;

DOI:10.1039/jr9480001310

Reference yield:

glyoxylic acid ethyl ester (924-44-7) + 4-methyl-1,2-diaminobenzene (496-72-0) → 7-methylquinoxalin-2(1H)-one (5762-65-2) + 6-methylquinoxaline-2(1H)-one (5762-64-1)

Guidance literature:

In ethanol; Reflux;

DOI:10.1039/d0cc05391k

upstream raw materials:

bromoacetic acid

4-methyl-1,2-diaminobenzene

butyl glyoxalate

glyoxylic acid ethyl ester

Downstream raw materials:

2-chloro-6-methylquinoxaline

6-methyl-2-(pentafluorophenyl)quinoxaline

6-methyl-2-(2,3,5,6-tetrafluorophenyl)quinoxaline

6-methyl-2-(2,3,4,6-tetrafluorophenyl)quinoxaline

Refernces