5-CHLORO-2-NITROCINNAMIC ACID

Base Information

• Chemical Name: 5-CHLORO-2-NITROCINNAMIC ACID
• CAS No.: 20357-28-2
• Molecular Formula: C₉H₆ClNO₄
• Molecular Weight: 227.604
• Hs Code.: 2916399090
• Mol file: 20357-28-2.mol

Synonyms:Cinnamicacid, 5-chloro-2-nitro- (8CI);

Chemical Property of 5-CHLORO-2-NITROCINNAMIC ACID

Chemical Property:

• Vapor Pressure: 1.05E-07mmHg at 25°C
• Melting Point: 174-175 °C
• Refractive Index: 1.663
• Boiling Point: 417.2 °C at 760 mmHg
• PKA: 3.91±0.10(Predicted)
• Flash Point: 206.1 °C
• PSA: 83.12000
• Density: 1.529 g/cm³
• LogP: 2.86920

Purity/Quality:

99% ^*data from raw suppliers

5-Chloro-2-nitrocinnamicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-CHLORO-2-NITROCINNAMIC ACID

There total 7 articles about 5-CHLORO-2-NITROCINNAMIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-chloro-2-nitrobenzaldehyde (6628-86-0) + acetic anhydride (108-24-7) → 5-chloro-2-nitro-cinnamic acid (20357-28-2)

Guidance literature:

With sodium acetate; at 145 ℃;

Reference yield:

3-nitro-benzaldehyde (99-61-6) → 5-chloro-2-nitro-cinnamic acid (20357-28-2)

Guidance literature:

Multi-step reaction with 3 steps

1: Reaktion ueber mehrere Stufen

2: concentrated sulfuric acid; KNO₃

3: sodium acetate / 145 °C

With sulfuric acid; sodium acetate; potassium nitrate;

Reference yield:

m-Chlorobenzaldehyde (587-04-2) → 5-chloro-2-nitro-cinnamic acid (20357-28-2)

Guidance literature:

Multi-step reaction with 2 steps

1: concentrated sulfuric acid; KNO₃

2: sodium acetate / 145 °C

With sulfuric acid; sodium acetate; potassium nitrate;

upstream raw materials:

5-chloro-2-nitrobenzaldehyde

acetic anhydride

3-nitro-benzaldehyde

m-Chlorobenzaldehyde

Downstream raw materials:

2-ethynyl-4-chloro-1-nitro-benzene

4-chloro-2-ethynylaniline

(5-chloro-2-nitro-phenyl)-propiolic acid

6-chloro-4(1H)-cinnoline