3-(4-Methoxynaphthyl)acrylic acid

Base Information

• Chemical Name: 3-(4-Methoxynaphthyl)acrylic acid
• CAS No.: 15971-30-9
• Molecular Formula: C14H12O3
• Molecular Weight: 228.24
• Hs Code.: 2918990090
• DSSTox Substance ID: DTXSID60397726
• Mol file: 15971-30-9.mol

Synonyms:3-(4-methoxynaphthyl)acrylic acid;3-(4-methoxynaphthalen-1-yl)prop-2-enoic acid;(E)-3-(4-methoxynaphthalen-1-yl)prop-2-enoic acid;DTXSID60397726;BDWSMCXLZKKQFV-UHFFFAOYSA-N;3- (4-methoxynaphthyl)acrylic acid;AKOS009157881;1-(2-carboxyethenyl)-4-methoxynaphthalene;FT-0681110

Chemical Property of 3-(4-Methoxynaphthyl)acrylic acid

Chemical Property:

• Vapor Pressure: 1.24E-08mmHg at 25°C
• Melting Point: 225 °C
• Refractive Index: 1.667
• Boiling Point: 426.8 °C at 760 mmHg
• PKA: 4.74±0.30(Predicted)
• Flash Point: 165.9 °C
• PSA: 46.53000
• Density: 1.246 g/cm³
• LogP: 2.94620
• XLogP3: 3.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 228.078644241
• Heavy Atom Count: 17
• Complexity: 298

Purity/Quality:

98%min ^*data from raw suppliers

3-(4-Methoxy-1-naphthyl)acrylicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=C(C2=CC=CC=C21)C=CC(=O)O

Technology Process of 3-(4-Methoxynaphthyl)acrylic acid

There total 7 articles about 3-(4-Methoxynaphthyl)acrylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl 3-(4'-methoxy-1'-naphthyl)-2-propenoate (15971-31-0) → 3-(4-methoxynaphthalen-1-yl)acrylic acid (15971-30-9,151539-64-9)

Guidance literature:

With water; sodium hydroxide; In ethanol; at 20 ℃;

DOI:10.1016/j.bmcl.2014.12.080

Reference yield:

4-methoxy-1-naphthaldehyde (15971-29-6) → 3-(4-methoxynaphthalen-1-yl)acrylic acid (15971-30-9,151539-64-9)

Guidance literature:

Reference yield:

1-hydroxymethyl-4-methoxy-naphthalene (16820-54-5) → 3-(4-methoxynaphthalen-1-yl)acrylic acid (15971-30-9,151539-64-9)

Guidance literature:

Multi-step reaction with 3 steps

1: pyridinium chlorochromate / dichloromethane / 20 °C

2: sodium hydride / tetrahydrofuran / 20 °C

3: sodium hydroxide; water / ethanol / 20 °C

With water; sodium hydride; pyridinium chlorochromate; sodium hydroxide; In tetrahydrofuran; ethanol; dichloromethane;

DOI:10.1016/j.bmcl.2014.12.080

upstream raw materials:

malonic acid

4-methoxy-1-naphthaldehyde

sodium acetate

acetic anhydride

Downstream raw materials:

β-(4-methoxy-1-naphthyl)propionic acid

1-methoxy-4-(1-phenylvinyl)naphthalene

Refernces